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@ARTICLE{Jones:275594,
      author       = {C. Jones and K. Straathof and M. Fouladi and D. Hargrave
                      and M. Prados and A. Resnick and F. Doz and D. T. W.
                      Jones$^*$ and S. Mueller},
      title        = {{E}valuating preclinical evidence for clinical translation
                      in childhood brain tumours: {G}uidelines from the {CONNECT},
                      {PNOC}, and {ITCC} brain networks.},
      journal      = {Frontiers in oncology},
      volume       = {13},
      issn         = {2234-943X},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DKFZ-2023-00805},
      pages        = {1167082},
      year         = {2023},
      abstract     = {Clinical outcomes for many childhood brain tumours remain
                      poor, despite our increasing understanding of the underlying
                      disease biology. Advances in molecular diagnostics have
                      refined our ability to classify tumour types and subtypes,
                      and efforts are underway across multiple international
                      paediatric neuro-oncology consortia to take novel biological
                      insights in the worst prognosis entities into innovative
                      clinical trials. Whilst for the first time we are designing
                      such studies on the basis of disease-specific biological
                      data, the levels of preclincial evidence in appropriate
                      model systems on which these trials are initiated is still
                      widely variable. We have considered these issues between
                      CONNECT, PNOC and ITCC-Brain, and developed a framework in
                      which we can assess novel concepts being brought forward for
                      possible clinical translation. Whilst not intended to be
                      proscriptive for every possible circumstance, these criteria
                      provide a basis for self-assessment of evidence by
                      laboratory scientists, and a platform for discussion and
                      rational decision-making prior to moving forward
                      clinically.},
      keywords     = {CNS (Other) / in vitro (Other) / in vivo (Other) / models
                      (Other) / pediatric (Other) / preclinical (Other) /
                      translational (Other)},
      cin          = {B360},
      ddc          = {610},
      cid          = {I:(DE-He78)B360-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37091147},
      pmc          = {pmc:PMC10114612},
      doi          = {10.3389/fonc.2023.1167082},
      url          = {https://inrepo02.dkfz.de/record/275594},
}