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@ARTICLE{Klp:275622,
      author       = {M. Külp and P. Larghero and J. Alten and G. Cario and C.
                      Eckert and A. Caye-Eude and H. Cavé and T. Schmachtel and
                      M. Bardini and G. Cazzaniga and P. De Lorenzo and M. G.
                      Valsecchi and H. Bonig and C. Meyer and M. A. Rieger$^*$ and
                      R. Marschalek},
      title        = {{T}he {EGR}3 regulome of infant {KMT}2{A}-r acute
                      lymphoblastic leukemia identifies differential expression of
                      {B}-lineage genes predictive for outcome.},
      journal      = {Leukemia},
      volume       = {37},
      number       = {6},
      issn         = {0887-6924},
      address      = {London},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2023-00824},
      pages        = {1216-1233},
      year         = {2023},
      note         = {2023 Jun;37(6):1216-1233},
      abstract     = {KMT2A-rearranged acute lymphoblastic infant leukemia
                      (KMT2A-r iALL) is associated with outsize risk of relapse
                      and relapse mortality. We previously reported strong
                      upregulation of the immediate early gene EGR3 in KMT2A::AFF1
                      iALL at relapse; now we provide analyses of the EGR3
                      regulome, which we assessed through binding and expression
                      target analysis of an EGR3-overexpressing t(4;11) cell
                      culture model. Our data identify EGR3 as a regulator of
                      early B-lineage commitment. Principal component analysis of
                      50 KMT2A-r iALL patients at diagnosis and 18 at relapse
                      provided strictly dichotomous separation of patients based
                      on the expression of four B-lineage genes. Absence of
                      B-lineage gene expression translates to more than two-fold
                      poorer long-term event-free survival. In conclusion, our
                      study presents four B-lineage genes with prognostic
                      significance, suitable for gene expression-based risk
                      stratification of KMT2A-r iALL patients.},
      cin          = {FM01},
      ddc          = {610},
      cid          = {I:(DE-He78)FM01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37100882},
      doi          = {10.1038/s41375-023-01895-z},
      url          = {https://inrepo02.dkfz.de/record/275622},
}