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@ARTICLE{Milsom:275628,
      author       = {M. Milsom$^*$ and M. Essers$^*$},
      title        = {{R}ecent advances in understanding the impact of infection
                      and inflammation on hematopoietic stem and progenitor
                      cells.},
      journal      = {Cells $\&$ development},
      volume       = {174},
      issn         = {2667-2901},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2023-00830},
      pages        = {203844},
      year         = {2023},
      note         = {#LA:A012#LA:A011# / 2023 Jun;174:203844},
      abstract     = {Just over one decade ago, it was discovered that
                      hematopoietic stem cells (HSCs) could directly respond to
                      inflammatory cytokines by mounting a proliferative response
                      thought to mediate the emergency production of mature blood
                      cells. In the intervening years, we have gained mechanistic
                      insight into this so-called activation process and have
                      started to learn such a response may come at a cost in terms
                      of ultimately resulting in HSC exhaustion and hematologic
                      dysfunction. In this review article, we report the progress
                      we have made in understanding the interplay between
                      infection, inflammation and HSCs during the funding period
                      of the Collaborative Research Center 873 'Maintenance and
                      Differentiation of Stem Cells in Development and Disease',
                      and place this work within the context of recent output by
                      others working within this field.},
      subtyp        = {Review Article},
      keywords     = {Aging (Other) / Clonal hematopoiesis (Other) /
                      Hematopoietic stem cells (Other) / Infection (Other) /
                      Inflammation (Other)},
      cin          = {A012 / A011},
      ddc          = {610},
      cid          = {I:(DE-He78)A012-20160331 / I:(DE-He78)A011-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37100116},
      doi          = {10.1016/j.cdev.2023.203844},
      url          = {https://inrepo02.dkfz.de/record/275628},
}