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@ARTICLE{Mekonnen:275650,
      author       = {D. Mekonnen and E. Nibret and A. Munshea and A. Derbie and
                      Y. Zenebe and A. Tadese and T. Birku and E. Tesfa and M. A.
                      Sinishaw and H. Getachew and Y. Gashaw and G. Yismaw and M.
                      Kebede$^*$ and B. Gelaw},
      title        = {{C}omparative serum lipid and immunohematological values
                      among adult pulmonary tuberculosis and tuberculosis
                      lymphadenitis cases and their association with sputum
                      bacilli load and time to culture positivity in
                      {N}orthwestern {E}thiopia.},
      journal      = {Lipids in health and disease},
      volume       = {22},
      number       = {1},
      issn         = {1476-511X},
      address      = {London},
      publisher    = {Biomed Central},
      reportid     = {DKFZ-2023-00838},
      pages        = {56},
      year         = {2023},
      abstract     = {The serum lipid and immunohematological values of
                      tuberculosis lymphadenitis (TBLN) patients is poorly
                      documented relative to pulmonary tuberculosis (PTB) cases.
                      Therefore, the aim of this study was to investigate the
                      serum lipid and immunohematological values of patients with
                      TBLN in comparison with PTB (PTB) patients.An
                      institution-based comparative cross-sectional study was
                      conducted in Northwest Ethiopia from March to December 2021.
                      The study participants were bacteriologically confirmed PTB
                      (n = 82) and TBLN (n = 94) cases with no known comorbidity
                      and whose ages was greater than 18 years and with no current
                      pregnancy. Independent sample t-test, one-way ANOVA, box
                      plot, and correlation matrix were used to analyze the
                      data.The body mass index (BMI), CD4 + T cell count, and
                      high-density lipoprotein-Cholesterol (HDL-C) values were
                      significantly higher among TBLN cases compared with PTB
                      cases. Additionally, the total white blood cell (WBC) count,
                      hemoglobin (Hb), total Cholesterol (CHO) and creatinine (Cr)
                      values were relatively higher among TBLN than PTB (P >
                      0.05). On the reverse, the platelet count and
                      triacylglycerol (TAG) values were relatively higher among
                      PTB than in TBLN cases. While the mean days of culture
                      positivity were 11.6 days for TBLN, the mean days of culture
                      positivity were 14.0 days for PTB. Anemia and serum lipid
                      values showed no correlation with sputum bacilli load and
                      time to culture positivity.Tuberculous lymphadenitis
                      patients were well-endowed with serum lipid, immunological
                      and nutritional status compared with PTB cases. Hence, the
                      high incidence rate of TBLN in Ethiopia could not be
                      explained by low peripheral immunohematological values,
                      malnutrition, Anemia, and dyslipidemia. Further study for
                      identifying the predictors for TBLN in Ethiopia is highly
                      desirable.},
      keywords     = {Ethiopia (Other) / Immunohematological values (Other) /
                      Pulmonary tuberculosis (Other) / Serum lipid (Other) /
                      Tuberculous lymphadenitis (Other)},
      cin          = {C020},
      ddc          = {570},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37106418},
      doi          = {10.1186/s12944-023-01821-3},
      url          = {https://inrepo02.dkfz.de/record/275650},
}