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@ARTICLE{Strnisch:275653,
      author       = {A. Strönisch and S. Märdian and A. Flörcken$^*$},
      title        = {{C}entralized and {I}nterdisciplinary {T}herapy
                      {M}anagement in the {T}reatment of {S}arcomas.},
      journal      = {Life},
      volume       = {13},
      number       = {4},
      issn         = {2075-1729},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-00841},
      pages        = {979},
      year         = {2023},
      abstract     = {Sarcoma treatment requires a high level of expertise due to
                      its rarity and heterogeneity. Sarcoma patients should,
                      therefore, be referred to an expert centre as early as
                      possible to ensure optimal treatment. Numerous studies have
                      been carried out to provide evidence for this strategy. In
                      compliance with the 2020 PRISMA guidelines, a systematic
                      search was conducted in PubMed, EMBASE, Ovid Medline,
                      ClinicalTrials.gov and Cochrane Library databases. The
                      subject of these studies was the centralised treatment of
                      adult sarcoma patients at expert centres and the use of
                      interdisciplinary tumour boards. Uncertainty in therapy,
                      delays in referral to expert centres, and limited access to
                      therapeutic modalities continue to be a challenge in sarcoma
                      therapy. At expert centres, diagnostic procedures were more
                      frequently and adequately performed, and treatment was
                      associated with an improvement in outcomes in the majority
                      of studies: patients benefited from longer survival, lower
                      local recurrence rates and a better postoperative outcome.
                      The implementation of an interdisciplinary tumour board was
                      associated with discrepant results. In a greater number of
                      studies, it was associated with a lower local relapse rate,
                      better overall survival and surgical outcome. In two
                      studies, however, a shorter overall survival was observed.
                      The establishment of expert centres and the consistent use
                      of interdisciplinary tumour boards are important structures
                      for ensuring multidisciplinary therapy approaches. There is
                      growing evidence that this holds great potential for
                      optimising sarcoma therapy.},
      subtyp        = {Review Article},
      keywords     = {cancer centre (Other) / expert centre (Other) /
                      interdisciplinary therapy (Other) / interdisciplinary tumour
                      board (Other) / multidisciplinary therapy (Other) / sarcoma
                      (Other)},
      cin          = {BE01},
      ddc          = {570},
      cid          = {I:(DE-He78)BE01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37109507},
      doi          = {10.3390/life13040979},
      url          = {https://inrepo02.dkfz.de/record/275653},
}