Home > Publications database > Synthesis of tritium-labeled Lu-PSMA-617: Alternative tool for biological evaluation of radiometal-based pharmaceuticals. > print

001     275767
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024 7 _ |a 10.1016/j.apradiso.2023.110819
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024 7 _ |a 0969-8043
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100 1 _ |a Bauder-Wüst, Ulrike
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245 _ _ |a Synthesis of tritium-labeled Lu-PSMA-617: Alternative tool for biological evaluation of radiometal-based pharmaceuticals.
260 _ _ |a Amsterdam [u.a.]
|c 2023
|b Elsevier Science
336 7 _ |a article
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520 _ _ |a This project focuses on the generation and evaluation of functional alternatives to radiometal-based pharmaceuticals supporting basic research and the in vitro developmental phase. Employing robust tritium chemistry and non-radioactive metal surrogates in two synthetic and labeling strategies resulted in ([ring-3H]Nal)PSMA-617 and ([α,ß-3H]Nal)PSMA-617. In particular, ([α,ß-3H]Nal)Lu-PSMA-617 exhibited high radiolytic as well as metal-complex stability and was compared to the clinically-established radiopharmaceutical [177Lu]Lu-PSMA-617. The cell-based assays confirmed the applicability of ([α,ß-3H]Nal)Lu-PSMA-617 as a substitute of [177Lu]Lu-PSMA-617 in pre-clinical biological settings.
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650 _ 7 |a Labeling chemistry
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650 _ 7 |a PSMA ligands
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650 _ 7 |a PSMA-617
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650 _ 7 |a Pharmaceutical development
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650 _ 7 |a Prostate cancer
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650 _ 7 |a Radiometals
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650 _ 7 |a Tritium
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700 1 _ |a Schäfer, Martin
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700 1 _ |a Winter, Ruth
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700 1 _ |a Remde, Yvonne
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700 1 _ |a Roscher, Mareike
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700 1 _ |a Breyl, Heinz
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700 1 _ |a Poethko, Thorsten
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700 1 _ |a Tömböly, Csaba
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700 1 _ |a Benesova-Schäfer, Martina
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773 _ _ |a 10.1016/j.apradiso.2023.110819
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