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@ARTICLE{Thurner:275780,
      author       = {L. Thurner and N. Fadle and E. Regitz and S. Roth and O.
                      Cetin and I. A. Kos and S. M. Hess and J. Bein and R. M.
                      Bohle and M. Vornanen and C. Sundström and L. De Leval and
                      E. Tiacci and P. Borchmann and A. Engert and V. Poeschel and
                      G. Held and E. C. Schwarz and F. Neumann and K.-D. Preuss
                      and M. Hoth and R. Küppers$^*$ and K. Lehman and M.-L.
                      Hansmann and S. L. Becker and M. Bewarder and S. Hartmann},
      title        = {{B}-cell receptor reactivity against {R}othia mucilaginosa
                      in nodular lymphocyte-predominant {H}odgkin lymphoma.},
      journal      = {Haematologica},
      volume       = {108},
      number       = {12},
      issn         = {0390-6078},
      address      = {Pavia},
      publisher    = {Ferrata Storti Foundation},
      reportid     = {DKFZ-2023-00874},
      pages        = {3347-3358},
      year         = {2023},
      note         = {2023 Dec 1;108(12):3347-3358},
      abstract     = {Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is
                      a Hodgkin lymphoma expressing functional B-cell receptors
                      (BCRs). Recently, we described a dual stimulation model of
                      IgD+ lymphocyte-predominant (LP) cells by Moraxella
                      catarrhalis antigen RpoC and its superantigen MID/hag,
                      associated with extralong CDR3s and HLA-DRB1*04 or
                      HLA-DRB1*07 haplotype. Aim of the present study was to
                      extend the antigen screening to further bacteria and
                      viruses. Fabs of 7 new and 15 previously reported cases were
                      analyzed. The reactivity of non-Moraxella spp.-reactive Fabs
                      against lysates of Rothia mucilaginosa was observed in 5/22
                      $(22.7\%)$ cases. Galactofuranosyl transferase (Gltf) and
                      2,3-butanediol dehydrogenase (Bdh) of R. mucilaginosa were
                      identified by comparative silver-and immunostaining in
                      two-dimensional gels, with subsequent mass spectrometry and
                      validation by Western blots and ELISA. Both R. mucilaginosa
                      Gltf and Bdh induced BCR pathway activation and
                      proliferation in vitro. Apoptosis was induced by recombinant
                      Gltf/ETA'- immunotoxin conjugates in DEV cells expressing
                      recombinant R. mucilaginosa-reactive BCRs. Reactivity
                      against M. catarrhalis RpoC was confirmed in 3/7 newly
                      expressed BCRs (total 10/22 reactive to Moraxella spp.),
                      resulting in 15/22 $(68.2\%)$ cases with BCR reactivity
                      against defined bacterial antigens. These findings
                      strengthen the hypothesis of bacterial trigger contributing
                      to subsets of NLPHL.},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37139600},
      doi          = {10.3324/haematol.2023.282698},
      url          = {https://inrepo02.dkfz.de/record/275780},
}