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| 001 | 275934 | ||
| 005 | 20240229154948.0 | ||
| 024 | 7 | _ | |a 10.1016/j.radonc.2023.109678 |2 doi |
| 024 | 7 | _ | |a pmid:37146766 |2 pmid |
| 024 | 7 | _ | |a 0167-8140 |2 ISSN |
| 024 | 7 | _ | |a 1879-0887 |2 ISSN |
| 024 | 7 | _ | |a altmetric:147896664 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2023-00922 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Scharl, Sophia |b 0 |
| 245 | _ | _ | |a Salvage radiotherapy is effective in patients with PSMA-PET-negative biochemical recurrence- results of a retrospective study. |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2023 |b Elsevier Science |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1687355745_6281 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2023 Jul;184:109678 |
| 520 | _ | _ | |a /Purpose: The present study aimed to assess whether SRT to the prostatic fossa should be initiated in a timely manner after detecting biochemical recurrence (BR) in patients with prostate cancer, when no correlate was identified with prostate-specific membrane antigen positron emission tomography (PSMA-PET).This retrospective, multicenter analysis included 1222 patients referred for PSMA-PET after a radical prostatectomy due to BR. Exclusion criteria were: pathological lymph node metastases, prostate-specific antigen (PSA) persistence, distant or lymph node metastases, nodal irradiation, and androgen deprivation therapy (ADT). This led to a cohort of 341 patients. Biochemical progression-free survival (BPFS) was the primary study endpoint.The median follow-up was 28.0 months. The 3-year BPFS was 71.6% in PET-negative cases and 80.8% in locally PET-positive cases. This difference was significant in univariate (p=0.019), but not multivariate analyses (p=0.366, HR: 1.46, 95%CI: 0.64-3.32). The 3-year BPFS in PET-negative cases was significantly influenced by age (p=0.005), initial pT3/4 (p<0.001), pathology scores (ISUP) ≥3 (p=0.026), and doses to fossa >70 Gy (p=0.027) in univariate analyses. In multivariate analyses, only age (HR: 1.096, 95%CI: 1.023-1.175, p=0.009) and PSA-doubling time (HR: 0.339, 95%CI: 0.139-0.826, p=0.017) remained significant.To our best knowledge, this study provided the largest SRT analysis in patients without ADT that were lymph node-negative on PSMA-PET. A multivariate analysis showed no significant difference in BPFS between locally PET-positive and PET-negative cases. These results supported the current EAU recommendation to initiate SRT in a timely manner after detecting BR in PET negative patients. |
| 536 | _ | _ | |a 315 - Bildgebung und Radioonkologie (POF4-315) |0 G:(DE-HGF)POF4-315 |c POF4-315 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de |
| 650 | _ | 7 | |a PET negative |2 Other |
| 650 | _ | 7 | |a PSMA PET-CT |2 Other |
| 650 | _ | 7 | |a prostate cancer |2 Other |
| 650 | _ | 7 | |a salvage radiotherapy |2 Other |
| 700 | 1 | _ | |a Zamboglou, Constantinos |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Strouthos, Iosif |b 2 |
| 700 | 1 | _ | |a Farolfi, Andrea |b 3 |
| 700 | 1 | _ | |a Serani, Francesca |b 4 |
| 700 | 1 | _ | |a Lanzafame, Helena |b 5 |
| 700 | 1 | _ | |a Giuseppe Morganti, Alessio |b 6 |
| 700 | 1 | _ | |a Trapp, Christian |b 7 |
| 700 | 1 | _ | |a Koerber, Stefan A |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Debus, Jürgen |0 P:(DE-He78)8714da4e45acfa36ce87c291443a9218 |b 9 |u dkfz |
| 700 | 1 | _ | |a Peeken, Jan C |0 P:(DE-HGF)0 |b 10 |
| 700 | 1 | _ | |a Vogel, Marco M E |0 P:(DE-HGF)0 |b 11 |
| 700 | 1 | _ | |a Vrachimis, Alexis |b 12 |
| 700 | 1 | _ | |a K B Spohn, Simon |0 P:(DE-HGF)0 |b 13 |
| 700 | 1 | _ | |a Ruf, Juri |0 P:(DE-HGF)0 |b 14 |
| 700 | 1 | _ | |a Grosu, Anca-Ligia |0 P:(DE-HGF)0 |b 15 |
| 700 | 1 | _ | |a Ceci, Francesco |b 16 |
| 700 | 1 | _ | |a Fendler, Wolfgang P |b 17 |
| 700 | 1 | _ | |a Bartenstein, Peter |b 18 |
| 700 | 1 | _ | |a Kroeze, Stephanie G C |b 19 |
| 700 | 1 | _ | |a Guckenberger, Matthias |b 20 |
| 700 | 1 | _ | |a Krafcsik, Manuel |b 21 |
| 700 | 1 | _ | |a Klopscheck, Christina |b 22 |
| 700 | 1 | _ | |a Fanti, Stefano |b 23 |
| 700 | 1 | _ | |a Hruby, George |b 24 |
| 700 | 1 | _ | |a Emmett, Louise |b 25 |
| 700 | 1 | _ | |a Belka, Claus |b 26 |
| 700 | 1 | _ | |a Stief, Christian |b 27 |
| 700 | 1 | _ | |a Schmidt-Hegemann, Nina-Sophie |b 28 |
| 700 | 1 | _ | |a Henkenberens, Christoph |b 29 |
| 700 | 1 | _ | |a Mayer, Benjamin |b 30 |
| 700 | 1 | _ | |a Miksch, Jonathan |b 31 |
| 700 | 1 | _ | |a Shelan, Mohamed |b 32 |
| 700 | 1 | _ | |a Aebersold, Daniel M |b 33 |
| 700 | 1 | _ | |a Thamm, Reinhard |b 34 |
| 700 | 1 | _ | |a Wiegel, Thomas |b 35 |
| 773 | _ | _ | |a 10.1016/j.radonc.2023.109678 |g p. 109678 - |0 PERI:(DE-600)1500707-8 |p 109678 |t Radiotherapy and oncology |v 184 |y 2023 |x 0167-8140 |
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