TY  - JOUR
AU  - Namgaladze, Dmitry
AU  - Brüne, Bernhard
TI  - Rapid glycolytic activation accompanying innate immune responses: mechanisms and function.
JO  - Frontiers in immunology
VL  - 14
SN  - 1664-3224
CY  - Lausanne
PB  - Frontiers Media
M1  - DKFZ-2023-00926
SP  - 1180488
PY  - 2023
AB  - Innate immune responses to pathogens, mediated by activation of pattern recognition receptors and downstream signal transduction cascades, trigger rapid transcriptional and epigenetic changes to support increased expression of pro-inflammatory cytokines and other effector molecules. Innate immune cells also rapidly rewire their metabolism. The most prominent metabolic alteration following innate immune activation is rapid up-regulation of glycolysis. In this mini-review, we summarize recent advances regarding the mechanisms of rapid glycolytic activation in innate immune cells, highlighting the relevant signaling components. We also discuss the impact of glycolytic activation on inflammatory responses, including the recently elucidated links of metabolism and epigenetics. Finally, we highlight unresolved mechanistic details of glycolytic activation and possible avenues of future research in this area.
KW  - Immunity, Innate
KW  - Signal Transduction
KW  - Receptors, Pattern Recognition: metabolism
KW  - Cytokines: metabolism
KW  - Glycolysis
KW  - dendritic cell (Other)
KW  - glycolysis (Other)
KW  - inflammation (Other)
KW  - macrophage (Other)
KW  - metabolism (Other)
KW  - pattern recognition receptors (Other)
KW  - Receptors, Pattern Recognition (NLM Chemicals)
KW  - Cytokines (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:37153593
C2  - pmc:PMC10158531
DO  - DOI:10.3389/fimmu.2023.1180488
UR  - https://inrepo02.dkfz.de/record/275938
ER  -