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@ARTICLE{Hiensch:275963,
      author       = {A. E. Hiensch and J. Beckhaus and L. Witlox and E. M.
                      Monninkhof and S. B. Schagen and J. K. van Vulpen and M. G.
                      Sweegers and R. U. Newton and N. K. Aaronson and D. A.
                      Galvão and K. Steindorf$^*$ and M. M. Stuiver and I.
                      Mesters and H. Knoop and M. M. Goedendorp and M. Bohus and
                      L. Thorsen and K.-H. Schulz and M. E. Schmidt$^*$ and C. M.
                      Ulrich and G. S. Sonke and W. H. van Harten and K. M.
                      Winters-Stone and M. J. Velthuis and D. R. Taaffe and W. van
                      Mechelen and M. J. Kersten and F. Nollet and J. Wiskemann
                      and L. M. Buffart and A. M. May},
      title        = {{M}oderators of exercise effects on self-reported cognitive
                      functioning in cancer survivors: an individual participant
                      data meta-analysis.},
      journal      = {Journal of cancer survivorship},
      volume       = {18},
      number       = {5},
      issn         = {1932-2259},
      address      = {New York, NY [u.a.]},
      publisher    = {Springer},
      reportid     = {DKFZ-2023-00945},
      pages        = {1492-1503},
      year         = {2024},
      note         = {2024 Oct;18(5):1492-1503},
      abstract     = {This individual participant data meta-analysis (IPD-MA)
                      assesses exercise effects on self-reported cognitive
                      functioning (CF) and investigates whether effects differ by
                      patient-, intervention-, and exercise-related
                      characteristics.IPD from 16 exercise RCTs, including 1987
                      patients across multiple types of non-metastatic cancer, was
                      pooled. A one-stage IPD-MA using linear mixed-effect models
                      was performed to assess exercise effects on self-reported CF
                      (z-score) and to identify whether the effect was moderated
                      by sociodemographic, clinical, intervention- and
                      exercise-related characteristics, or fatigue, depression,
                      anxiety, and self-reported CF levels at start of the
                      intervention (i.e., baseline). Models were adjusted for
                      baseline CF and included a random intercept at study level
                      to account for clustering of patients within studies. A
                      sensitivity analysis was performed in patients who reported
                      cognitive problems at baseline.Minimal significant
                      beneficial exercise effects on self-reported CF (β=-0.09
                      [-0.16; -0.02]) were observed, with slightly larger effects
                      when the intervention was delivered post-treatment (n=745,
                      β=-0.13 [-0.24; -0.02]), and no significant effect during
                      cancer treatment (n=1,162, β=-0.08 [-0.18; 0.02]). Larger
                      effects were observed in interventions of 12 weeks or
                      shorter (β=-0.14 [-0.25; -0.04]) or 24 weeks or longer
                      (β=-0.18 [-0.32; -0.02]), whereas no effects were observed
                      in interventions of 12-24 weeks (β=0.01 [-0.13; 0.15]).
                      Exercise interventions were most beneficial when provided to
                      patients without anxiety symptoms (β=-0.10 [-0.19; -0.02])
                      or after completion of treatment in patients with cognitive
                      problems (β=-0.19 [-0.31; -0.06]). No other significant
                      moderators were identified.This cross-cancer IPD
                      meta-analysis observed small beneficial exercise effects on
                      self-reported CF when the intervention was delivered
                      post-treatment, especially in patients who reported
                      cognitive problems at baseline.This study provides some
                      evidence to support the prescription of exercise to improve
                      cognitive functioning. Sufficiently powered trials are
                      warranted to make more definitive recommendations and
                      include these in the exercise guidelines for cancer
                      survivors.},
      keywords     = {Cancer (Other) / Cognitive functioning (Other) / Exercise
                      (Other) / Individual participant data meta-analysis (Other)
                      / Survivorship (Other)},
      cin          = {C110},
      ddc          = {610},
      cid          = {I:(DE-He78)C110-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37160571},
      doi          = {DOI: 10.1007/s11764-023-01392-3},
      url          = {https://inrepo02.dkfz.de/record/275963},
}