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@ARTICLE{Wellbrock:275967,
      author       = {M. Wellbrock and C. Spix and C. M. Ronckers and D. Grabow
                      and A.-L. Filbert and A. Borkhardt$^*$ and D. Wollschläger
                      and F. Erdmann},
      title        = {{T}emporal patterns of childhood cancer survival 1991 to
                      2016: {A} nationwide register-study based on data from the
                      {G}erman {C}hildhood {C}ancer {R}egistry.},
      journal      = {International journal of cancer},
      volume       = {153},
      number       = {4},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2023-00949},
      pages        = {742-755},
      year         = {2023},
      note         = {2023 Aug 15;153(4):742-755},
      abstract     = {Childhood cancer is the leading disease-related cause of
                      death among under 15 year olds in Europe. Since primary
                      preventive measures are lacking, improving survival
                      probabilities and long-term well-being remain primary goals.
                      With this report, we provide the first long-term assessment
                      and interpretation of patterns in childhood cancer survival
                      in Germany, covering a period of 30 years. Using data from
                      the German Childhood Cancer Registry, we assessed temporal
                      patterns of cancer survival among children (0-14 years)
                      diagnosed in Germany from 1991 to 2016, by cancer type, age
                      at diagnosis and sex. We calculated overall survival (OS)
                      and average annual percentage changes of the respective
                      5-year OS estimates. OS improved across all cancer types,
                      age groups as well as for boys and girls over time.
                      Five-year OS for all childhood cancers combined increased
                      from $77.8\%$ in 1991-1995 to $86.5\%$ in 2011-2016, with
                      stronger improvements during the early 1990s. The most
                      pronounced survival improvement was seen for acute myeloid
                      leukaemia, at $2\%$ annually and 5-year OS recently reaching
                      $81.5\%.$ Survival improvements for some diagnoses such as
                      neuroblastoma, renal tumours and bone tumours have flattened
                      out. Tremendous enhancements in diagnostics, treatment and
                      supportive care have affected average survival improvements
                      for most cancer types. Recently, survival improvements have
                      decelerated overall and for some cancer types, it plateaued
                      at an unsatisfactory level. As not all children benefited
                      equally from the survival improvements, personal factors
                      (eg, socioeconomic circumstances, health literacy, access to
                      care) likely affect individual prognosis and warrant further
                      investigation.},
      keywords     = {Childhood cancer (Other) / German Childhood Cancer Registry
                      (Other) / Survival analysis (Other) / Temporal survival
                      patterns (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37158619},
      doi          = {DOI: 10.1002/ijc.34556},
      url          = {https://inrepo02.dkfz.de/record/275967},
}