% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Schmidt:276057,
      author       = {A. Schmidt$^*$ and I. Adelabu and C. Nelson and S. Nantogma
                      and V. G. Kiselev and M. Zaitsev and A. Abdurraheem and H.
                      de Maissin$^*$ and M. S. Rosen and S. Lehmkuhl and S. Appelt
                      and T. Theis and E. Y. Chekmenev},
      title        = {13{C} {R}adiofrequency {A}mplification by {S}timulated
                      {E}mission of {R}adiation {T}hreshold {S}ensing of
                      {C}hemical {R}eactions.},
      journal      = {Journal of the American Chemical Society},
      volume       = {145},
      number       = {20},
      issn         = {0002-7863},
      address      = {Washington, DC},
      publisher    = {ACS Publications},
      reportid     = {DKFZ-2023-00963},
      pages        = {11121-11129},
      year         = {2023},
      note         = {2023 May 24;145(20):11121-11129},
      abstract     = {Conventional nuclear magnetic resonance (NMR) enables
                      detection of chemicals and their transformations by exciting
                      nuclear spin ensembles with a radio-frequency pulse followed
                      by detection of the precessing spins at their characteristic
                      frequencies. The detected frequencies report on chemical
                      reactions in real time and the signal amplitudes scale with
                      concentrations of products and reactants. Here, we employ
                      Radiofrequency Amplification by Stimulated Emission of
                      Radiation (RASER), a quantum phenomenon producing coherent
                      emission of 13C signals, to detect chemical transformations.
                      The 13C signals are emitted by the negatively hyperpolarized
                      biomolecules without external radio frequency pulses and
                      without any background signal from other, nonhyperpolarized
                      spins in the ensemble. Here, we studied the hydrolysis of
                      hyperpolarized ethyl-[1-13C]acetate to hyperpolarized
                      [1-13C]acetate, which was analyzed as a model system by
                      conventional NMR and 13C RASER. The chemical transformation
                      of 13C RASER-active species leads to complete and abrupt
                      disappearance of reactant signals and delayed, abrupt
                      reappearance of a frequency-shifted RASER signal without
                      destroying 13C polarization. The experimentally observed
                      'quantum' RASER threshold is supported by simulations.},
      cin          = {FR01},
      ddc          = {540},
      cid          = {I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37172079},
      doi          = {10.1021/jacs.3c00776},
      url          = {https://inrepo02.dkfz.de/record/276057},
}