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@ARTICLE{Pelaez:276059,
      author       = {M. Pelaez and M. M. Stuiver and M. Broekman and K. H.
                      Schmitz and E. M. Zopf and D. Clauss and Y. Wengström and
                      F. Rosenberger and K. Steindorf$^*$ and A. Urruticoechea and
                      A. M. May},
      title        = {{E}arly {D}etection of {B}rain {M}etastases in a
                      {S}upervised {E}xercise {P}rogram for {P}atients with
                      {A}dvanced {B}reast {C}ancer: {A} {C}ase {R}eport.},
      journal      = {Medicine and science in sports and exercise},
      volume       = {55},
      number       = {10},
      issn         = {0025-7990},
      address      = {[Erscheinungsort nicht ermittelbar]},
      publisher    = {Ovid},
      reportid     = {DKFZ-2023-00965},
      pages        = {1745-1749},
      year         = {2023},
      note         = {2023 Oct 1;55(10):1745-1749},
      abstract     = {Around $25\%$ of metastatic breast cancer (mBC) patients
                      develop brain metastases, which vastly affects their overall
                      survival and quality of life (QoL). According to the current
                      clinical guidelines, regular magnetic resonance imaging
                      screening is not recommended unless patients have recognized
                      central nervous system (CNS) related symptoms.The patient
                      participated in the EFFECT study, a randomized controlled
                      trial aimed to assess the effects of a 9-month structured,
                      individualized and supervised exercise intervention on QoL,
                      fatigue and other cancer and treatment-related side effects
                      in patients with mBC. She attended the training sessions
                      regularly and was supervised by the same trainer throughout
                      the exercise program. In month 7 of participation, her
                      exercise trainer detected subtle symptoms (e.g. changes in
                      movement pattern, eye movement or balance), which had not
                      been noticed or reported by the patient herself or her
                      family, and which were unlikely to have been detected by the
                      oncologist or other health care providers at that point
                      since symptoms were exercise related. When suspicion of
                      brain metastases was brought to the attention of the
                      oncologist by the exercise trainer, the response was
                      immediate, and led to early detection and treatment of brain
                      metastases.The brain metastases of this patient were
                      detected earlier due to the recognition of subtle symptoms
                      detected by her exercise trainer and the trust and rapid
                      action by the clinician. The implementation of physical
                      exercise programs for cancer patients requires well-trained
                      professionals who know how to recognize possible alterations
                      in patients and also, good communication between trainers
                      and the medical team to enable the necessary actions to be
                      taken.},
      cin          = {C110},
      ddc          = {796},
      cid          = {I:(DE-He78)C110-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37170950},
      doi          = {10.1249/MSS.0000000000003213},
      url          = {https://inrepo02.dkfz.de/record/276059},
}