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@ARTICLE{Kasi:276067,
author = {P. B. Kasi and V. R. Mallela and F. Ambrozkiewicz and A.
Trailin and V. Liška and K. Hemminki$^*$},
title = {{T}heranostics {N}anomedicine {A}pplications for
{C}olorectal {C}ancer and {M}etastasis: {R}ecent
{A}dvances.},
journal = {International journal of molecular sciences},
volume = {24},
number = {9},
issn = {1422-0067},
address = {Basel},
publisher = {Molecular Diversity Preservation International},
reportid = {DKFZ-2023-00973},
pages = {7922},
year = {2023},
note = {#LA:C020#},
abstract = {Colorectal cancer (CRC) is the third most common cancer
worldwide, and metastatic CRC is a fatal disease. The
CRC-affected tissues show several molecular markers that
could be used as a fresh strategy to create newer methods of
treating the condition. The liver and the peritoneum are
where metastasis occurs most frequently. Once the tumor has
metastasized to the liver, peritoneal carcinomatosis is
frequently regarded as the disease's final stage. However,
nearly $50\%$ of CRC patients with peritoneal carcinomatosis
do not have liver metastases. New diagnostic and therapeutic
approaches must be developed due to the disease's poor
response to present treatment choices in advanced stages and
the necessity of an accurate diagnosis in the early stages.
Many unique and amazing nanomaterials with promise for both
diagnosis and treatment may be found in nanotechnology.
Numerous nanomaterials and nanoformulations, including
carbon nanotubes, dendrimers, liposomes, silica
nanoparticles, gold nanoparticles, metal-organic frameworks,
core-shell polymeric nano-formulations, and nano-emulsion
systems, among others, can be used for targeted anticancer
drug delivery and diagnostic purposes in CRC. Theranostic
approaches combined with nanomedicine have been proposed as
a revolutionary approach to improve CRC detection and
treatment. This review highlights recent studies, potential,
and challenges for the development of nanoplatforms for the
detection and treatment of CRC.},
subtyp = {Review Article},
keywords = {Humans / Nanomedicine: methods / Peritoneal Neoplasms /
Precision Medicine / Nanotubes, Carbon / Gold / Metal
Nanoparticles / Nanoparticles: therapeutic use / Colorectal
Neoplasms: diagnosis / Colorectal Neoplasms: drug therapy /
Theranostic Nanomedicine / Drug Delivery Systems: methods /
cancer therapy (Other) / clinical status (Other) /
colorectal cancer (Other) / nanomedicine (Other) /
theranostics (Other) / Nanotubes, Carbon (NLM Chemicals) /
Gold (NLM Chemicals)},
cin = {C020},
ddc = {540},
cid = {I:(DE-He78)C020-20160331},
pnm = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
pid = {G:(DE-HGF)POF4-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:37175627},
pmc = {pmc:PMC10178331},
doi = {10.3390/ijms24097922},
url = {https://inrepo02.dkfz.de/record/276067},
}