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@ARTICLE{Obrecht:276077,
      author       = {D. Obrecht and M. Mynarek and M. Stickan-Verfürth and B.
                      Bison and U. Schüller and K. Pajtler$^*$ and C. Hagel and
                      U.-W. Thomale and G. Fleischhack and B. Timmermann and S.
                      Rutkowski},
      title        = {{P}ediatric {I}ntracranial {E}pendymoma - {R}ecommendations
                      for {F}irst-{L}ine {T}reatment from the {G}erman {HIT}-{MED}
                      study group.[{K}inder und {J}ugendliche mit intrakraniellem
                      {E}pendymom – {E}mpfehlungen der
                      {HIT}-{MED}-{S}tudiengruppe der {GPOH} zur
                      {E}rstlinientherapie].},
      journal      = {Klinische Pädiatrie},
      volume       = {235},
      number       = {3},
      issn         = {0300-8630},
      address      = {Stuttgart},
      publisher    = {Thieme},
      reportid     = {DKFZ-2023-00983},
      pages        = {167 - 177},
      year         = {2023},
      abstract     = {Biological subtypes of ependymoma (EPN) have been
                      introduced by the recent WHO classification and appear to
                      have great impact on the clinical course, but have not yet
                      found their way into clinical risk stratification. Further,
                      the overall unfavorable prognosis underlines the fact that
                      current therapeutic strategies need further evaluation for
                      improvement. To date, there is no international consensus
                      regarding first-line treatment for children with
                      intracranial EPN. Extent of resection is known to be the
                      most important clinical risk factor, leading to the
                      consensus that consequent evaluation for re-surgery of
                      postoperative residual tumor needs to have highest priority.
                      Furthermore, efficacy of local irradiation is unquestioned
                      and recommended for patients aged>1 year. In contrast,
                      efficacy of chemotherapy is still under discussion. The
                      European trial SIOP Ependymoma II aims at evaluating
                      efficacy of different chemotherapy elements, leading to the
                      recommendation to include German patients. The BIOMECA
                      study, as biological accompanying study, aims at identifying
                      new prognostic parameters. These results might help to
                      develop targeted therapies for unfavorable biological
                      subtypes. For patient who are not qualified for inclusion
                      into the interventional strata, the HIT-MED Guidance 5.2
                      provides specific recommendations. This article is meant as
                      an overview of national guidelines regarding diagnostics and
                      treatment as well as of treatment according to the SIOP
                      Ependymoma II trial protocol.},
      keywords     = {Child / Humans / Brain Neoplasms: drug therapy / Brain
                      Neoplasms: pathology / Prognosis / Combined Modality Therapy
                      / Risk Factors / Ependymoma: diagnosis / Ependymoma: therapy
                      / Ependymoma: pathology},
      cin          = {B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37172610},
      doi          = {10.1055/a-2070-7572},
      url          = {https://inrepo02.dkfz.de/record/276077},
}