%0 Journal Article
%A Deng, Maximilian
%A Hinz, Felix
%A Harrabi, Semi
%A Sturm, Dominik
%A Sill, Martin
%A Korshunov, Andrey
%A Eichkorn, Tanja
%A Hörner-Rieber, Juliane
%A Herfarth, Klaus
%A Jungk, Christine
%A Unterberg, Andreas
%A Pfister, Stefan
%A Wick, Wolfgang
%A von Deimling, Andreas
%A Jones, David
%A Debus, Jürgen
%A Sahm, Felix
%A König, Laila
%T Clinical outcome following surgical resection and radiotherapy in adult patients with pleomorphic xanthoastrocytoma as defined by DNA methylation profiling.
%J Neuro-oncology practice
%V 10
%N 3
%@ 2054-2577
%C Oxford
%I Oxford Univ. Press
%M DKFZ-2023-00990
%P 307 - 314
%D 2023
%X Molecular brain tumor classification using DNA methylation profiling has revealed that the methylation-class of pleomorphic xanthoastrocytoma (mcPXA) comprised a substantial portion of divergent initial diagnoses, which had been established based on histology alone. This study aimed to characterize the survival outcome in patients with mcPXAs-in light of the diverse selected treatment regimes.A retrospective cohort of adult mcPXAs were analyzed in regard to their progression-free survival following surgical resection and postoperative radiotherapy. Radiotherapy treatment plans were correlated with follow-up images to characterize the pattern of relapse. Treatment toxicities and molecular tumor characteristics were further analyzed.Divergent initial histological diagnoses were encountered in 40.7
%K DNA methylation profiling (Other)
%K Pleomorphic xanthoastrocytoma (Other)
%K glioma (Other)
%K molecular diagnostics (Other)
%K radiotherapy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37188167
%2 pmc:PMC10180362
%R 10.1093/nop/npad004
%U https://inrepo02.dkfz.de/record/276084