TY  - JOUR
AU  - Deng, Maximilian
AU  - Hinz, Felix
AU  - Harrabi, Semi
AU  - Sturm, Dominik
AU  - Sill, Martin
AU  - Korshunov, Andrey
AU  - Eichkorn, Tanja
AU  - Hörner-Rieber, Juliane
AU  - Herfarth, Klaus
AU  - Jungk, Christine
AU  - Unterberg, Andreas
AU  - Pfister, Stefan
AU  - Wick, Wolfgang
AU  - von Deimling, Andreas
AU  - Jones, David
AU  - Debus, Jürgen
AU  - Sahm, Felix
AU  - König, Laila
TI  - Clinical outcome following surgical resection and radiotherapy in adult patients with pleomorphic xanthoastrocytoma as defined by DNA methylation profiling.
JO  - Neuro-oncology practice
VL  - 10
IS  - 3
SN  - 2054-2577
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2023-00990
SP  - 307 - 314
PY  - 2023
AB  - Molecular brain tumor classification using DNA methylation profiling has revealed that the methylation-class of pleomorphic xanthoastrocytoma (mcPXA) comprised a substantial portion of divergent initial diagnoses, which had been established based on histology alone. This study aimed to characterize the survival outcome in patients with mcPXAs-in light of the diverse selected treatment regimes.A retrospective cohort of adult mcPXAs were analyzed in regard to their progression-free survival following surgical resection and postoperative radiotherapy. Radiotherapy treatment plans were correlated with follow-up images to characterize the pattern of relapse. Treatment toxicities and molecular tumor characteristics were further analyzed.Divergent initial histological diagnoses were encountered in 40.7
KW  - DNA methylation profiling (Other)
KW  - Pleomorphic xanthoastrocytoma (Other)
KW  - glioma (Other)
KW  - molecular diagnostics (Other)
KW  - radiotherapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37188167
C2  - pmc:PMC10180362
DO  - DOI:10.1093/nop/npad004
UR  - https://inrepo02.dkfz.de/record/276084
ER  -