% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Deng:276084,
      author       = {M. Deng and F. Hinz$^*$ and S. Harrabi and D. Sturm$^*$ and
                      M. Sill$^*$ and A. Korshunov$^*$ and T. Eichkorn and J.
                      Hörner-Rieber$^*$ and K. Herfarth and C. Jungk and A.
                      Unterberg and S. Pfister$^*$ and W. Wick$^*$ and A. von
                      Deimling$^*$ and D. Jones$^*$ and J. Debus$^*$ and F.
                      Sahm$^*$ and L. König},
      title        = {{C}linical outcome following surgical resection and
                      radiotherapy in adult patients with pleomorphic
                      xanthoastrocytoma as defined by {DNA} methylation
                      profiling.},
      journal      = {Neuro-oncology practice},
      volume       = {10},
      number       = {3},
      issn         = {2054-2577},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2023-00990},
      pages        = {307 - 314},
      year         = {2023},
      abstract     = {Molecular brain tumor classification using DNA methylation
                      profiling has revealed that the methylation-class of
                      pleomorphic xanthoastrocytoma (mcPXA) comprised a
                      substantial portion of divergent initial diagnoses, which
                      had been established based on histology alone. This study
                      aimed to characterize the survival outcome in patients with
                      mcPXAs-in light of the diverse selected treatment regimes.A
                      retrospective cohort of adult mcPXAs were analyzed in regard
                      to their progression-free survival following surgical
                      resection and postoperative radiotherapy. Radiotherapy
                      treatment plans were correlated with follow-up images to
                      characterize the pattern of relapse. Treatment toxicities
                      and molecular tumor characteristics were further
                      analyzed.Divergent initial histological diagnoses were
                      encountered in $40.7\%.$ There was no significant difference
                      in local progression-free (PFS) and overall survival (OS)
                      following gross total or subtotal resection. Postoperative
                      radiotherapy was completed in $81\%$ (22/27) following
                      surgical intervention. Local PFS was $54.4\%$ $(95\%$ CI:
                      $35.3-84.0\%)$ and OS was $81.3\%$ $(95\%$ CI: $63.8-100\%)$
                      after 3 years following postoperative radiotherapy. Initial
                      relapses post-radiotherapy were primarily located in the
                      previous tumor location and/or the planning target volume
                      (PTV) (12/13). All patients in our cohort demonstrated the
                      prognostically favorable pTERT-wildtype mcPXA.Our study
                      demonstrated that adult patients with mcPXAs display a worse
                      progression-free survival compared to the reported WHO grade
                      2 PXAs. Future matched-pair analyses are required with a
                      non-irradiated cohort to elucidate the benefit of
                      postoperative radiotherapy in adult patients with mcPXAs.},
      keywords     = {DNA methylation profiling (Other) / Pleomorphic
                      xanthoastrocytoma (Other) / glioma (Other) / molecular
                      diagnostics (Other) / radiotherapy (Other)},
      cin          = {B300 / HD01 / B360 / B062 / E050 / B320},
      ddc          = {610},
      cid          = {I:(DE-He78)B300-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)B360-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)E050-20160331 / I:(DE-He78)B320-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37188167},
      pmc          = {pmc:PMC10180362},
      doi          = {10.1093/nop/npad004},
      url          = {https://inrepo02.dkfz.de/record/276084},
}