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| Home > Publications database > Clinical outcome following surgical resection and radiotherapy in adult patients with pleomorphic xanthoastrocytoma as defined by DNA methylation profiling. > print |
| 001 | 276084 | ||
| 005 | 20240918103627.0 | ||
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| 100 | 1 | _ | |a Deng, Maximilian |b 0 |
| 245 | _ | _ | |a Clinical outcome following surgical resection and radiotherapy in adult patients with pleomorphic xanthoastrocytoma as defined by DNA methylation profiling. |
| 260 | _ | _ | |a Oxford |c 2023 |b Oxford Univ. Press |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1726648560_16238 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 520 | _ | _ | |a Molecular brain tumor classification using DNA methylation profiling has revealed that the methylation-class of pleomorphic xanthoastrocytoma (mcPXA) comprised a substantial portion of divergent initial diagnoses, which had been established based on histology alone. This study aimed to characterize the survival outcome in patients with mcPXAs-in light of the diverse selected treatment regimes.A retrospective cohort of adult mcPXAs were analyzed in regard to their progression-free survival following surgical resection and postoperative radiotherapy. Radiotherapy treatment plans were correlated with follow-up images to characterize the pattern of relapse. Treatment toxicities and molecular tumor characteristics were further analyzed.Divergent initial histological diagnoses were encountered in 40.7%. There was no significant difference in local progression-free (PFS) and overall survival (OS) following gross total or subtotal resection. Postoperative radiotherapy was completed in 81% (22/27) following surgical intervention. Local PFS was 54.4% (95% CI: 35.3-84.0%) and OS was 81.3% (95% CI: 63.8-100%) after 3 years following postoperative radiotherapy. Initial relapses post-radiotherapy were primarily located in the previous tumor location and/or the planning target volume (PTV) (12/13). All patients in our cohort demonstrated the prognostically favorable pTERT-wildtype mcPXA.Our study demonstrated that adult patients with mcPXAs display a worse progression-free survival compared to the reported WHO grade 2 PXAs. Future matched-pair analyses are required with a non-irradiated cohort to elucidate the benefit of postoperative radiotherapy in adult patients with mcPXAs. |
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| 650 | _ | 7 | |a DNA methylation profiling |2 Other |
| 650 | _ | 7 | |a Pleomorphic xanthoastrocytoma |2 Other |
| 650 | _ | 7 | |a glioma |2 Other |
| 650 | _ | 7 | |a molecular diagnostics |2 Other |
| 650 | _ | 7 | |a radiotherapy |2 Other |
| 700 | 1 | _ | |a Hinz, Felix |0 P:(DE-He78)8126cfb1cc3fa7fa8fd5c20410c6d863 |b 1 |u dkfz |
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| 700 | 1 | _ | |a Eichkorn, Tanja |b 6 |
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| 700 | 1 | _ | |a Herfarth, Klaus |b 8 |
| 700 | 1 | _ | |a Jungk, Christine |b 9 |
| 700 | 1 | _ | |a Unterberg, Andreas |b 10 |
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| 700 | 1 | _ | |a König, Laila |b 17 |
| 773 | _ | _ | |a 10.1093/nop/npad004 |g Vol. 10, no. 3, p. 307 - 314 |0 PERI:(DE-600)2768945-1 |n 3 |p 307 - 314 |t Neuro-oncology practice |v 10 |y 2023 |x 2054-2577 |
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