TY  - JOUR
AU  - Kraskowski, Oliver
AU  - Stratmann, Jan A
AU  - Wiesweg, Marcel
AU  - Eberhardt, Wilfried
AU  - Metzenmacher, Martin
AU  - Schmid, Kurt W
AU  - Herold, Thomas
AU  - Schildhaus, Hans-Ulrich
AU  - Darwiche, Kaid
AU  - Aigner, Clemens
AU  - Stuschke, Martin
AU  - Laue, Katharina
AU  - Zaun, Gregor
AU  - Kasper, Stefan
AU  - Hense, Jörg
AU  - Sebastian, Martin
AU  - Schuler, Martin
AU  - Pogorzelski, Michael
TI  - Favorable survival outcomes in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer sequentially treated with a tyrosine kinase inhibitor and osimertinib in a real-world setting.
JO  - Journal of cancer research and clinical oncology
VL  - 149
IS  - 11
SN  - 0301-1585
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2023-01000
SP  - 9243-9252
PY  - 2023
N1  - 2023 Sep;149(11):9243-9252
AB  - EGFR tyrosine kinase inhibitor (TKI) therapy in EGFR-mutated lung cancer is limited by acquired resistance. In half of the patients treated with first/second-generation (1st/2nd gen) TKI, resistance is associated with EGFR p.T790M mutation. Sequential treatment with osimertinib is highly active in such patients. Currently, there is no approved targeted second-line option for patients receiving first-line osimertinib, which thus may not be the best choice for all patients. The present study aimed to evaluate the feasibility and efficacy of a sequential TKI treatment with 1st/2nd gen TKI, followed by osimertinib in a real-world setting.Patients with EGFR-mutated lung cancer treated at two major comprehensive cancer centers were retrospectively analyzed by the Kaplan-Meier method and log rank test.A cohort of 150 patients, of which 133 received first-line treatment with a first/second gen EGFR TKI, and 17 received first-line osimertinib, was included. Median age was 63.9 years, 55
KW  - EGFR T790M mutation (Other)
KW  - EGFR-mutated NSCLC (Other)
KW  - Osimertinib (Other)
KW  - Rebiopsy (Other)
KW  - Second line (Other)
KW  - Sequential therapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37198447
DO  - DOI:10.1007/s00432-023-04839-3
UR  - https://inrepo02.dkfz.de/record/276100
ER  -