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@ARTICLE{Anker:276222,
      author       = {M. S. Anker and A. Lena and E. J. Roeland and J. Porthun
                      and S. Schmitz and S. Hadzibegovic and P. Sikorski and U.
                      Wilkenshoff and A.-K. Fröhlich and L. V. Ramer and M. Rose
                      and J. Eucker and T. Rassaf and M. Totzeck and L. H. Lehmann
                      and S. von Haehling and A. J. S. Coats and T. Friede and J.
                      Butler and S. D. Anker and H. Riess and U. Landmesser and L.
                      Bullinger$^*$ and U. Keller$^*$ and J. Ahn},
      title        = {{P}atient-reported ability to walk 4 m and to wash: {N}ew
                      clinical endpoints and predictors of survival in patients
                      with pre-terminal cancer.},
      journal      = {Journal of cachexia, sarcopenia and muscle},
      volume       = {14},
      number       = {4},
      issn         = {2190-5991},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2023-01033},
      pages        = {1670-1681},
      year         = {2023},
      note         = {2023 Aug;14(4):1670-1681},
      abstract     = {Maintaining the ability to perform self-care is a critical
                      goal in patients with cancer. We assessed whether the
                      patient-reported ability to walk 4 m and wash oneself
                      predict survival in patients with pre-terminal cancer.We
                      performed a prospective observational study on 169
                      consecutive hospitalized patients with cancer $(52\%$
                      female, 64 ± 12 years) and an estimated 1-12 months
                      prognosis at an academic, inpatient palliative care unit.
                      Patients answered functional questions for 'today', 'last
                      week', and 'last month', performed patient-reported outcomes
                      (PROs), and physical function assessments.Ninety-two
                      $(54\%)$ patients reported the ability to independently walk
                      4 m and 100 $(59\%)$ to wash 'today'. The median number of
                      days patients reported the ability to walk 4 m and wash were
                      6 (IQR 0-7) and 7 (0-7) days ('last week'); and 27 (5-30)
                      and 26 (10-30) days ('last month'). In the last week, $32\%$
                      of patients were unable to walk 4 m on every day and $10\%$
                      could walk on 1-3 days; $30\%$ were unable to wash on every
                      day and $10\%$ could wash on 1-3 days. In the last months,
                      $14\%$ of patients were unable to walk 4 m on every day and
                      $10\%$ could only walk on 1-10 days; $12\%$ were unable to
                      wash on every day and $11\%$ could wash on 1-10 days. In
                      patients who could walk 'today' average 4 m gait speed was
                      0.78 ± 0.28 m/s. Patients who reported impaired walking and
                      washing experienced more symptoms (dyspnoea, exertion, and
                      oedema) and decreased physical function (higher Eastern
                      Cooperative Oncology Group Performance Status, and lower
                      Karnofsky Performance Status and hand-grip strength [unable
                      vs. able to walk 'today': 205 ± 87 vs. 252 ± 78 Newton, P
                      = 0.001; unable vs. able to wash 'today': 204 ± 86 vs. 250
                      ± 80 Newton, P = 0.001]). During the 27 months of
                      observation, 152 $(90\%)$ patients died (median survival 46
                      days). In multivariable Cox proportional hazards regression
                      analyses, all tested parameters were independent predictors
                      of survival: walking 4 m 'today' (HR 0.63, P = 0.015), 'last
                      week' (per 1 day: HR 0.93, P = 0.011), 'last month' (per 1
                      day: HR 0.98, P = 0.012), 4 m gait speed (per 1 m/s: HR
                      0.45, P = 0.002), and washing 'today' (HR 0.67, P = 0.024),
                      'last week (per 1 day HR 0.94, p=0.019), and 'last month'
                      (per 1 day HR 0.99, P = 0.040). Patients unable to walk and
                      wash experienced the shortest survival and most reduced
                      functional status.In patients with pre-terminal cancer, the
                      self-reported ability to walk 4 m and wash were independent
                      predictors of survival and associated with decreased
                      functional status.},
      keywords     = {Cancer (Other) / Independence (Other) / Palliative care
                      (Other) / Self-care (Other) / Walking ability (Other) /
                      Washing ability (Other)},
      cin          = {BE01},
      ddc          = {610},
      cid          = {I:(DE-He78)BE01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37222009},
      doi          = {10.1002/jcsm.13247},
      url          = {https://inrepo02.dkfz.de/record/276222},
}