%0 Journal Article
%A Haller, Paul M
%A Goßling, Alina
%A Magnussen, Christina
%A Brenner, Hermann
%A Schöttker, Ben
%A Iacoviello, Licia
%A Costanzo, Simona
%A Kee, Frank
%A Koenig, Wolfgang
%A Linneberg, Allan
%A Sujana, Chaterina
%A Thorand, Barbara
%A Salomaa, Veikko
%A Niiranen, Teemu J
%A Söderberg, Stefan
%A Völzke, Henry
%A Dörr, Marcus
%A Sans, Susana
%A Padró, Teresa
%A Felix, Stephan B
%A Nauck, Matthias
%A Petersmann, Astrid
%A Palmieri, Luigi
%A Donfrancesco, Chiara
%A De Ponti, Roberto
%A Veronesi, Giovanni
%A Ferrario, Marco M
%A Kuulasmaa, Kari
%A Zeller, Tanja
%A Ojeda, Francisco
%A Blankenberg, Stefan
%A Westermann, Dirk
%T Biomarker-based prediction of fatal and non-fatal cardiovascular outcomes in individuals with diabetes mellitus.
%J European journal of preventive cardiology
%V 30
%N 12
%@ 2047-4873
%C Oxford
%I Oxford University Press
%M DKFZ-2023-01035
%P 1218-1226
%D 2023
%Z 2023 Sep 6;30(12):1218-1226
%X The role of biomarkers in predicting cardiovascular outcomes in high-risk individuals is not well established. We aimed to investigate benefits of adding biomarkers to cardiovascular risk assessment in individuals with and without diabetes.We used individual-level data of 95,292 individuals of the European population harmonized in the BiomarCaRE consortium and investigated the prognostic ability of high-sensitivity cardiac troponin I (hs-cTnI), N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP). Cox-regression models were used to determine adjusted hazard ratios (adj-HR) of diabetes and log-transformed biomarkers for fatal and non-fatal cardiovascular events. Models were compared using the likelihood ratio test. Stratification by specific biomarker cut-offs was performed for crude time-to-event analysis using Kaplan-Meier-plots.Overall, 6,090 (6.4
%K NT-proBNP (Other)
%K biomarkers (Other)
%K cardiovascular events (Other)
%K diabetes (Other)
%K hs-CRP (Other)
%K hs-cTnI (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37079290
%R 10.1093/eurjpc/zwad122
%U https://inrepo02.dkfz.de/record/276226