TY  - JOUR
AU  - Haller, Paul M
AU  - Goßling, Alina
AU  - Magnussen, Christina
AU  - Brenner, Hermann
AU  - Schöttker, Ben
AU  - Iacoviello, Licia
AU  - Costanzo, Simona
AU  - Kee, Frank
AU  - Koenig, Wolfgang
AU  - Linneberg, Allan
AU  - Sujana, Chaterina
AU  - Thorand, Barbara
AU  - Salomaa, Veikko
AU  - Niiranen, Teemu J
AU  - Söderberg, Stefan
AU  - Völzke, Henry
AU  - Dörr, Marcus
AU  - Sans, Susana
AU  - Padró, Teresa
AU  - Felix, Stephan B
AU  - Nauck, Matthias
AU  - Petersmann, Astrid
AU  - Palmieri, Luigi
AU  - Donfrancesco, Chiara
AU  - De Ponti, Roberto
AU  - Veronesi, Giovanni
AU  - Ferrario, Marco M
AU  - Kuulasmaa, Kari
AU  - Zeller, Tanja
AU  - Ojeda, Francisco
AU  - Blankenberg, Stefan
AU  - Westermann, Dirk
TI  - Biomarker-based prediction of fatal and non-fatal cardiovascular outcomes in individuals with diabetes mellitus.
JO  - European journal of preventive cardiology
VL  - 30
IS  - 12
SN  - 2047-4873
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2023-01035
SP  - 1218-1226
PY  - 2023
N1  - 2023 Sep 6;30(12):1218-1226
AB  - The role of biomarkers in predicting cardiovascular outcomes in high-risk individuals is not well established. We aimed to investigate benefits of adding biomarkers to cardiovascular risk assessment in individuals with and without diabetes.We used individual-level data of 95,292 individuals of the European population harmonized in the BiomarCaRE consortium and investigated the prognostic ability of high-sensitivity cardiac troponin I (hs-cTnI), N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP). Cox-regression models were used to determine adjusted hazard ratios (adj-HR) of diabetes and log-transformed biomarkers for fatal and non-fatal cardiovascular events. Models were compared using the likelihood ratio test. Stratification by specific biomarker cut-offs was performed for crude time-to-event analysis using Kaplan-Meier-plots.Overall, 6,090 (6.4
KW  - NT-proBNP (Other)
KW  - biomarkers (Other)
KW  - cardiovascular events (Other)
KW  - diabetes (Other)
KW  - hs-CRP (Other)
KW  - hs-cTnI (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37079290
DO  - DOI:10.1093/eurjpc/zwad122
UR  - https://inrepo02.dkfz.de/record/276226
ER  -