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000276233 1001_ $$00000-0002-6405-5057$$aPreuss, Stephanie F$$b0$$eFirst author
000276233 245__ $$aSystemic Reprogramming of Endothelial Cell Signaling in Metastasis and Cachexia.
000276233 260__ $$aStanford, Calif.$$bHighWire Press$$c2023
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000276233 520__ $$aProliferating cancer cells secrete a multitude of factors impacting metabolism, interorgan communication, and tumor progression. The distribution of tumor-derived factors to distant organs occurs via the circulation, which provides an extensive reactive surface lined by endothelial cells. Primary tumor-derived proteins impact cancer progression by modulating endothelial cell activation at the (pre-)metastatic niche, which affects tumor cell dissemination as well as the outgrowth of seeded metastatic cells into overt tumors. In addition, new insight indicates that endothelial cell signaling contributes to metabolic symptoms of cancer, including cancer-associated cachexia, opening a new field of vascular metabolism research. This review addresses how tumor-derived factors systemically affect endothelial cell signaling and activation and impact distant organs as well as tumor progression.
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000276233 650_7 $$2Other$$aangiocrine signaling
000276233 650_7 $$2Other$$acachexia
000276233 650_7 $$2Other$$ametastasis
000276233 650_7 $$2Other$$asystemic signaling
000276233 650_7 $$2Other$$avascular endothelium
000276233 650_7 $$2NLM Chemicals$$aNeoplasm Proteins
000276233 650_2 $$2MeSH$$aHumans
000276233 650_2 $$2MeSH$$aEndothelial Cells
000276233 650_2 $$2MeSH$$aCachexia
000276233 650_2 $$2MeSH$$aSignal Transduction
000276233 650_2 $$2MeSH$$aNeoplasm Proteins
000276233 7001_ $$0P:(DE-He78)7660b2d1778e67ce6a7c7d93cdcac372$$aGrieshober, Denise$$b1$$eFirst author$$udkfz
000276233 7001_ $$0P:(DE-He78)2e92d0ae281932fc7347d819fec36b0b$$aAugustin, Hellmut$$b2$$eLast author$$udkfz
000276233 773__ $$0PERI:(DE-600)2005759-3$$a10.1152/physiol.00001.2023$$gVol. 38, no. 4, p. 000 - 000$$n4$$p189–202$$tPhysiology$$v38$$x1548-9213$$y2023
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