TY  - JOUR
AU  - Preuss, Stephanie F
AU  - Grieshober, Denise
AU  - Augustin, Hellmut
TI  - Systemic Reprogramming of Endothelial Cell Signaling in Metastasis and Cachexia.
JO  - Physiology
VL  - 38
IS  - 4
SN  - 1548-9213
CY  - Stanford, Calif.
PB  - HighWire Press
M1  - DKFZ-2023-01042
SP  - 189–202
PY  - 2023
N1  - #EA:A190#LA:A190#
AB  - Proliferating cancer cells secrete a multitude of factors impacting metabolism, interorgan communication, and tumor progression. The distribution of tumor-derived factors to distant organs occurs via the circulation, which provides an extensive reactive surface lined by endothelial cells. Primary tumor-derived proteins impact cancer progression by modulating endothelial cell activation at the (pre-)metastatic niche, which affects tumor cell dissemination as well as the outgrowth of seeded metastatic cells into overt tumors. In addition, new insight indicates that endothelial cell signaling contributes to metabolic symptoms of cancer, including cancer-associated cachexia, opening a new field of vascular metabolism research. This review addresses how tumor-derived factors systemically affect endothelial cell signaling and activation and impact distant organs as well as tumor progression.
KW  - Humans
KW  - Endothelial Cells
KW  - Cachexia
KW  - Signal Transduction
KW  - Neoplasm Proteins
KW  - angiocrine signaling (Other)
KW  - cachexia (Other)
KW  - metastasis (Other)
KW  - systemic signaling (Other)
KW  - vascular endothelium (Other)
KW  - Neoplasm Proteins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:37222464
DO  - DOI:10.1152/physiol.00001.2023
UR  - https://inrepo02.dkfz.de/record/276233
ER  -