TY  - JOUR
AU  - Mei, Riccardo
AU  - Kessler, Lukas
AU  - Pabst, Kim M
AU  - Weber, Manuel
AU  - Schimdkonz, Christian
AU  - Rischpler, Christoph
AU  - Zacho, Helle Damgaard
AU  - Hope, Thomas
AU  - Schwarzenböck, Sarah M
AU  - Allen-Auerbach, Martin
AU  - Emmett, Louise
AU  - Ferdinandus, Justin
AU  - Unterrainer, Marcus
AU  - Schaarschmidt, Benedikt M
AU  - Umutlu, Lale
AU  - Farolfi, Andrea
AU  - Castellucci, Paolo
AU  - Nanni, Cristina
AU  - Telo, Silvi
AU  - Fanti, Stefano
AU  - Herrmann, Ken
AU  - Fendler, Wolfgang P
TI  - 68Ga-FAPI PET/CT Interobserver Agreement on Tumor Assessment: An International Multicenter Prospective Study.
JO  - Journal of nuclear medicine
VL  - 64
IS  - 7
SN  - 0097-9058
CY  - New York, NY
PB  - Soc.
M1  - DKFZ-2023-01046
SP  - 1043-1048
PY  - 2023
N1  - 2023 Jul;64(7):1043-1048
AB  - 68Ga-fibroblast activation protein inhibitors (FAPIs) are promising radiotracers for cancer imaging, with emerging data in the recent years. Nonetheless, the interobserver agreement on 68Ga-FAPI PET/CT study interpretations in cancer patients remains poorly understood. Methods: 68Ga-FAPI PET/CT was performed on 50 patients with various tumor entities (sarcoma [n = 10], colorectal cancer [n = 10], pancreatic adenocarcinoma [n = 10], genitourinary cancer [n = 10], and other types of cancer [n = 10]). Fifteen masked observers reviewed and interpreted the images using a standardized approach for local, local nodal, and metastatic involvement. Observers were grouped by experience as having a low (<30 prior 68Ga-FAPI PET/CT studies; n = 5), intermediate (30-300 studies; n = 5), or high level of experience (>300 studies; n = 5). Two independent readers with a high level of experience and unmasked to clinical information, histopathology, tumor markers, and follow-up imaging (CT/MRI or PET/CT) served as the standard of reference (SOR). Observer groups were compared by overall agreement (percentage of patients matching SOR) and Fleiss κ with mean and corresponding 95
KW  - FAPI (Other)
KW  - PET (Other)
KW  - cancer imaging (Other)
KW  - fibroblast activation protein (Other)
KW  - interobserver agreement (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37230530
DO  - DOI:10.2967/jnumed.122.265245
UR  - https://inrepo02.dkfz.de/record/276244
ER  -