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@ARTICLE{Kuo:276245,
      author       = {P. H. Kuo and D. C. Yoo and R. Avery and M. Seltzer and J.
                      Calais and J. Nagarajah and W. A. Weber and W. P.
                      Fendler$^*$ and M. S. Hofman and B. J. Krause and M.
                      Brackman and E. Kpamegan and S. Ghebremariam and T. Benson
                      and A. M. Catafau and A. T. Kendi},
      title        = {{A} {VISION} {S}ubstudy of {R}eader {A}greement on
                      68{G}a-{PSMA}-11 {PET}/{CT} {S}can {I}nterpretation to
                      {D}etermine {P}atient {E}ligibility for 177{L}u-{PSMA}-617
                      {R}adioligand {T}herapy.},
      journal      = {Journal of nuclear medicine},
      volume       = {64},
      number       = {8},
      issn         = {0097-9058},
      address      = {New York, NY},
      publisher    = {Soc.},
      reportid     = {DKFZ-2023-01047},
      pages        = {1259-1265},
      year         = {2023},
      note         = {2023 Aug;64(8):1259-1265},
      abstract     = {68Ga-gozetotide (68Ga-PSMA-11) is used to identify
                      prostate-specific membrane antigen (PSMA)-positive tumors on
                      PET scans. In the VISION study, 68Ga-PSMA-11 was used to
                      determine the eligibility of patients with metastatic
                      castration-resistant prostate cancer for treatment with
                      177Lu-vipivotide tetraxetan (177Lu-PSMA-617), based on
                      predefined read criteria. This substudy aimed to investigate
                      the interreader variability and intrareader reproducibility
                      of visual assessments of 68Ga-PSMA-11 PET/CT scans using the
                      VISION read criteria and evaluate the agreement between read
                      results for this and the VISION study. Methods: In VISION,
                      68Ga-PSMA-11 PET/CT scans were centrally read as inclusion
                      cases if they had at least 1 PSMA-positive lesion and no
                      PSMA-negative lesions that fulfilled the exclusion criteria.
                      In this substudy, 125 PET/CT scans (75 inclusion and 50
                      exclusion cases) were randomly selected from VISION and
                      retrospectively assessed by 3 independent central readers. A
                      random subset of 20 cases (12 inclusion and 8 exclusion
                      cases) was recoded for assessment of intrareader
                      reproducibility. Classification of cases as inclusion or
                      exclusion cases was based on the VISION read criteria.
                      Overall interreader variability was assessed by Fleiss
                      κ-statistics, and pairwise variability and intrareader
                      reproducibility were assessed by Cohen κ-statistics.
                      Results: For interreader variability, the readers agreed on
                      $77\%$ of cases (overall average agreement rate, 0.85;
                      Fleiss κ, 0.60 $[95\%$ CI, 0.50-0.70]). The pairwise
                      agreement rate was 0.82, 0.88, and 0.84, and the
                      corresponding Cohen κ was 0.54 $(95\%$ CI, 0.38-0.71), 0.67
                      $(95\%$ CI, 0.52-0.83), and 0.59 $(95\%$ CI, 0.43-0.75),
                      respectively. For intrareader reproducibility, the agreement
                      rate was 0.90, 0.90, and 0.95, and the corresponding Cohen
                      κ was 0.78 $(95\%$ CI, 0.49-0.99), 0.76 $(95\%$ CI,
                      0.46-0.99), and 0.89 $(95\%$ CI, 0.67-0.99), respectively.
                      The number of actual VISION inclusion cases out of the total
                      number of cases scored as inclusion in this substudy was 71
                      of 93 (agreement rate, 0.76; $95\%$ CI, 0.66-0.85) for
                      reader 1, 70 of 88 (0.80; 0.70-0.87) for reader 2, and 73 of
                      96 (0.76; 0.66-0.84) for reader 3. All readers agreed on 66
                      of 75 VISION inclusion cases. Conclusion:
                      Moderate-to-substantial interreader agreement and
                      substantial-to-almost perfect intrareader reproducibility
                      for 68Ga-PSMA-11 PET/CT scan assessment using the VISION
                      read criteria were observed. The read rules applied in
                      VISION can be readily learned and demonstrate good
                      reproducibility.},
      keywords     = {PET/CT (Other) / PSMA (Other) / prostate cancer (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37230533},
      doi          = {10.2967/jnumed.122.265077},
      url          = {https://inrepo02.dkfz.de/record/276245},
}