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| 024 | 7 | _ | |a 10.1016/j.clnu.2023.05.009 |2 doi |
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| 024 | 7 | _ | |a 0261-5614 |2 ISSN |
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| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Gwenzi, Tafirenyika |0 P:(DE-He78)35a941418cdcc6c595b7a8a19e355599 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Effects of vitamin D supplementation on inflammatory response in patients with cancer and precancerous lesions: Systematic review and meta-analysis of randomized trials. |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2023 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1687349125_6281 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2023 Jul;42(7):1142-1150 / #EA:C120#LA:C120#LA:C070# |
| 520 | _ | _ | |a Inflammation plays a key role in tumor development and progression. Vitamin D has potential tumor suppressing effects through modulation of inflammatory processes. The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) was to summarize and evaluate the effects of vitamin D3 supplementation (VID3S) on serum inflammatory biomarkers among patients with cancer or pre-cancerous lesions.We searched PubMed, Web of Science and Cochrane databases until November 2022. The effects of VID3S were estimated from pooled standardized mean differences (SMDs) with their 95% confidence intervals (CIs) for inflammatory biomarker follow-up levels between intervention and control groups.Meta-analysis of eight RCTs (total of 592 patients with cancer or pre-cancerous conditions) showed that VID3S significantly lowered levels of serum tumor necrosis factor (TNF)-α (SMD [95%CI]: -1.65 [-3.07; -0.24]). VID3S also resulted in statistically non-significantly lower serum levels of interleukin (IL)-6 (SMD [95%CI]: -0.83, [-1.78; 0.13]) and C-reactive protein (CRP) (SMD [95%CI]: -0.09, [-0.35; 0.16]), whereas IL-10 levels were unaltered (SMD [95%CI]: -0.00, [-0.50; 0.49]).Our study shows evidence of a significant reduction of TNF-α levels by VID3S for patients with cancer or precancerous lesions. Patients with cancer or precancerous lesions may benefit from personalized VID3S in suppressing tumour-promoting inflammatory response.CRD42022295694. |
| 536 | _ | _ | |a 313 - Krebsrisikofaktoren und Prävention (POF4-313) |0 G:(DE-HGF)POF4-313 |c POF4-313 |f POF IV |x 0 |
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| 650 | _ | 7 | |a Biomarker |2 Other |
| 650 | _ | 7 | |a Cancer |2 Other |
| 650 | _ | 7 | |a Inflammation |2 Other |
| 650 | _ | 7 | |a Precancer |2 Other |
| 650 | _ | 7 | |a Vitamin D3 supplement |2 Other |
| 700 | 1 | _ | |a Zhu, Anna |0 P:(DE-He78)e71d98af5fac4f81eb58e74b7b3095c2 |b 1 |u dkfz |
| 700 | 1 | _ | |a Schrotz-King, Petra |0 P:(DE-He78)01ef71f71b01a3ec3b698653fd43fe86 |b 2 |u dkfz |
| 700 | 1 | _ | |a Schöttker, Ben |0 P:(DE-He78)c67a12496b8aac150c0eef888d808d46 |b 3 |u dkfz |
| 700 | 1 | _ | |a Hoffmeister, Michael |0 P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f |b 4 |u dkfz |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 5 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1016/j.clnu.2023.05.009 |g p. S0261561423001516 |0 PERI:(DE-600)2009052-3 |n 7 |p 1142-1150 |t Clinical nutrition |v 42 |y 2023 |x 0261-5614 |
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