%0 Journal Article
%A Regnery, Sebastian
%A Leiner, Lukas
%A Buchele, Carolin
%A Hoegen, Philipp
%A Sandrini, Elisabetta
%A Held, Thomas
%A Deng, Maximilian
%A Eichkorn, Tanja
%A Rippke, Carolin
%A Renkamp, C Katharina
%A König, Laila
%A Lang, Kristin
%A Adeberg, Sebastian
%A Debus, Jürgen
%A Klüter, Sebastian
%A Hörner-Rieber, Juliane
%T Comparison of different dose accumulation strategies to estimate organ doses after stereotactic magnetic resonance-guided adaptive radiotherapy.
%J Radiation oncology
%V 18
%N 1
%@ 1748-717X
%C London
%I BioMed Central
%M DKFZ-2023-01060
%P 92
%D 2023
%Z #LA:E050#
%X Re-irradiation is frequently performed in the era of precision oncology, but previous doses to organs-at-risk (OAR) must be assessed to avoid cumulative overdoses. Stereotactic magnetic resonance-guided online adaptive radiotherapy (SMART) enables highly precise ablation of tumors close to OAR. However, OAR doses may change considerably during adaptive treatment, which complicates potential re-irradiation. We aimed to compare the baseline plan with different dose accumulation techniques to inform re-irradiation.We analyzed 18 patients who received SMART to lung or liver tumors inside prospective databases. Cumulative doses were calculated inside the planning target volumes (PTV) and OAR for the adapted plans and theoretical non-adapted plans via (1) cumulative dose volume histograms (DVH sum plan) and (2) deformable image registration (DIR)-based dose accumulation to planning images (DIR sum plan). We compared cumulative dose parameters between the baseline plan, DVH sum plan and DIR sum plan using equivalent doses in 2 Gy fractions (EQD2).Individual patients presented relevant increases of near-maximum doses inside the proximal bronchial tree, spinal cord, heart and gastrointestinal OAR when comparing adaptive treatment to the baseline plans. The spinal cord near-maximum doses were significantly increased in the liver patients (D2
%K Deformable image Registration (Other)
%K Dose accumulation (Other)
%K Image-guided Radiotherapy (IGRT) (Other)
%K Liver Cancer (Other)
%K MR-guided adaptive radiotherapy (Other)
%K Pulmonary Cancer (Other)
%K Stereotactic body Radiotherapy (SABR) (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37248504
%R 10.1186/s13014-023-02284-7
%U https://inrepo02.dkfz.de/record/276330