%0 Journal Article
%A Donson, Andrew M
%A Bertrand, Kelsey C
%A Riemondy, Kent A
%A Gao, Dexiang
%A Zhuang, Yonghua
%A Sanford, Bridget
%A Norris, Gregory A
%A Chapman, Rebecca J
%A Fu, Rui
%A Willard, Nicholas
%A Griesinger, Andrea M
%A de Sousa, Graziella Ribeiro
%A Amani, Vladimir
%A Grimaldo, Enrique
%A Hankinson, Todd C
%A Booker, Ffyona
%A Sill, Martin
%A Grundy, Richard G
%A Pajtler, Kristian
%A Ellison, David W
%A Foreman, Nicholas K
%A Ritzmann, Timothy A
%T Significant increase of high-risk chromosome 1q gain and 6q loss at recurrence in posterior fossa group A ependymoma: a multicenter study.
%J Neuro-Oncology
%V 25
%N 10
%@ 1522-8517
%C Oxford
%I Oxford Univ. Press
%M DKFZ-2023-01062
%P 1854-1867
%D 2023
%Z 2023 Oct 3;25(10):1854-1867
%X Ependymoma (EPN) posterior fossa group A (PFA) has the highest rate of recurrence and the worst prognosis of all EPN molecular groups. At relapse, it is typically incurable even with re-resection and re-irradiation. The biology of recurrent PFA remains largely unknown, however, the increasing use of surgery at first recurrence has now provided access to clinical samples to facilitate a better understanding of this.In this large longitudinal international multicenter study, we examined matched samples of primary and recurrent disease from PFA patients to investigate the biology of recurrence.DNA methylome derived copy number variants (CNVs) revealed large scale chromosome gains and losses at recurrence. CNV changes were dominated by chromosome 1q gain and/or 6q loss, both previously identified as high-risk factors in PFA, which were present in 23
%K chromosomal instability (Other)
%K ependymoma (Other)
%K prognosis (Other)
%K recurrence (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37246777
%R 10.1093/neuonc/noad096
%U https://inrepo02.dkfz.de/record/276332