TY  - JOUR
AU  - Forster, Tobias
AU  - Köhler, Clara
AU  - Dorn, Melissa
AU  - Häfner, Matthias Felix
AU  - Arians, Nathalie
AU  - König, Laila
AU  - Harrabi, Semi Ben
AU  - Schlampp, Ingmar
AU  - Weykamp, Fabian
AU  - Meixner, Eva
AU  - Lang, Kristin
AU  - Heinrich, Vanessa
AU  - Weidner, Nicola
AU  - Hüsing, Johannes
AU  - Wallwiener, Markus
AU  - Golatta, Michael
AU  - Hennigs, André
AU  - Heil, Jörg
AU  - Hof, Holger
AU  - Krug, David
AU  - Debus, Jürgen
AU  - Hörner-Rieber, Juliane
TI  - Non-inferiority of local control and comparable toxicity of intensity-modulated radiotherapy with simultaneous integrated boost in breast cancer: 5-year results of the IMRT-MC2 phase III trial: IMRT-SIB is non-inferior to 3-D-CRT-seqB in RT for BC patients.
JO  - International journal of radiation oncology, biology, physics
VL  - 117
IS  - 4
SN  - 0360-3016
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2023-01063
SP  - 857-868
PY  - 2023
N1  - 2023 Nov 15;117(4):857-868 / #LA:E050#
AB  - The IMRT-MC2 trial was conducted to demonstrate non-inferiority of conventionally fractionated intensity-modulated radiotherapy with simultaneous integrated boost (IMRT-SIB) to 3-D-conformal radiotherapy with sequential boost (3-D-CRT-seqB) for adjuvant breast radiotherapy.A total of 502 patients were randomized between 2011 and 2015 for the prospective, multicenter, phase-III-trial (NCT01322854). 5-year results of late toxicity (LENT-SOMA), overall survival, disease-free survival, distant disease-free survival, cosmesis (Harvard scale) and local control (non-inferiority margin at hazard ratio of 3.5) were analyzed after a median follow-up of 62 months.The 5-year LC rate for the IMRT-SIB arm was non-inferior to the control arm (98.7
KW  - 3-D-conformal radiotherapy (Other)
KW  - 5-year follow-up (Other)
KW  - Breast cancer (Other)
KW  - intensity-modulated radiotherapy (IMRT) (Other)
KW  - local control (Other)
KW  - overall survival (Other)
KW  - sequential boost irradiation (Other)
KW  - simultaneously integrated boost (SIB) (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37244626
DO  - DOI:10.1016/j.ijrobp.2023.05.035
UR  - https://inrepo02.dkfz.de/record/276333
ER  -