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@ARTICLE{Aglago:276355,
      author       = {E. K. Aglago and A. E. Kim and Y. Lin and C. Qu and M.
                      Evangelou and Y. Ren and J. Morrison and D. Albanes and V.
                      Arndt$^*$ and E. L. Barry and J. W. Baurley and S. I. Berndt
                      and S. A. Bien and D. T. Bishop and E. Bouras and H.
                      Brenner$^*$ and D. D. Buchanan and A. Budiarto and R.
                      Carreras-Torres and G. Casey and T. W. Cenggoro and A. T.
                      Chan and J. Chang-Claude$^*$ and X. Chen$^*$ and D. V. Conti
                      and M. Devall and V. Díez-Obrero and N. Dimou and D. Drew
                      and J. C. Figueiredo and S. Gallinger and G. G. Giles and S.
                      B. Gruber and A. Gsur and M. J. Gunter and H. Hampel and S.
                      Harlid and A. Hidaka and T. A. Harrison and M.
                      Hoffmeister$^*$ and J. R. Huyghe and M. A. Jenkins and K.
                      Jordahl and A. D. Joshi and E. S. Kawaguchi and T. O. Keku
                      and A. Kundaje and S. C. Larsson and L. Le Marchand and J.
                      P. Lewinger and L. Li and B. M. Lynch and B. Mahesworo and
                      M. Mandic$^*$ and M. Obón-Santacana and V. Moreno and N.
                      Murphy and H. Nan and R. Nassir and P. A. Newcomb and S.
                      Ogino and J. Ose and R. K. Pai and J. R. Palmer and N.
                      Papadimitriou and B. Pardamean and A. R. Peoples and E. A.
                      Platz and J. D. Potter and R. L. Prentice and G. Rennert and
                      E. Ruiz-Narvaez and L. C. Sakoda and P. C. Scacheri and S.
                      L. Schmit and R. E. Schoen and A. Shcherbina and M. L.
                      Slattery and M. C. Stern and Y.-R. Su and C. M. Tangen and
                      S. N. Thibodeau and D. C. Thomas and Y. Tian and C. M.
                      Ulrich and F. J. B. van Duijnhoven and B. Van Guelpen and K.
                      Visvanathan and P. Vodicka and J. Wang and E. White and A.
                      Wolk and M. O. Woods and A. H. Wu and N. Zemlianskaia and L.
                      Hsu and W. J. Gauderman and U. Peters and K. K. Tsilidis and
                      P. T. Campbell},
      title        = {{A} genetic locus within the {FMN}1/{GREM}1 gene region
                      interacts with body mass index in colorectal cancer risk.},
      journal      = {Cancer research},
      volume       = {83},
      number       = {15},
      issn         = {0099-7013},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2023-01075},
      pages        = {2572-2583},
      year         = {2023},
      note         = {2023 Aug 1;83(15):2572-2583},
      abstract     = {Colorectal cancer (CRC) risk can be impacted by genetic,
                      environmental, and lifestyle factors, including diet and
                      obesity. Gene-environment (G×E) interactions can provide
                      biological insights into the effects of obesity on CRC risk.
                      Here, we assessed potential genome-wide G×E interactions
                      between body mass index (BMI) and common single nucleotide
                      polymorphisms (SNPs) for CRC risk using data from 36,415 CRC
                      cases and 48,451 controls from three international CRC
                      consortia (CCFR, CORECT, and GECCO). The G×E tests included
                      the conventional logistic regression using multiplicative
                      terms (one-degree of freedom, 1DF test), the two-step EDGE
                      method, and the joint 3DF test, each of which is powerful
                      for detecting G×E interactions under specific conditions.
                      BMI was associated with higher CRC risk. The two-step
                      approach revealed a statistically significant G×BMI
                      interaction located within the Formin 1/Gremlin 1
                      (FMN1/GREM1) gene region (rs58349661). This SNP was also
                      identified by the 3DF test, with a suggestive statistical
                      significance in the 1DF test. Among participants with the CC
                      genotype of rs58349661, overweight and obesity categories
                      were associated with higher CRC risk, whereas null
                      associations were observed across BMI categories in those
                      with the TT genotype. Using data from three large
                      international consortia, this study discovered a locus in
                      the FMN1/GREM1 gene region that interacts with BMI on the
                      association with CRC risk. Further studies should examine
                      the potential mechanisms through which this locus modifies
                      the etiologic link between obesity and CRC.},
      cin          = {C071 / C070 / C020 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C071-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)C020-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37249599},
      doi          = {10.1158/0008-5472.CAN-22-3713},
      url          = {https://inrepo02.dkfz.de/record/276355},
}