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000276420 1001_ $$aFunke, Viktoria L E$$b0
000276420 245__ $$aGroup-specific cellular metabolism in Medulloblastoma.
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000276420 520__ $$aCancer metabolism influences multiple aspects of tumorigenesis and causes diversity across malignancies. Although comprehensive research has extended our knowledge of molecular subgroups in medulloblastoma (MB), discrete analysis of metabolic heterogeneity is currently lacking. This study seeks to improve our understanding of metabolic phenotypes in MB and their impact on patients' outcomes.Data from four independent MB cohorts encompassing 1,288 patients were analysed. We explored metabolic characteristics of 902 patients (ICGC and MAGIC cohorts) on bulk RNA level. Moreover, data from 491 patients (ICGC cohort) were searched for DNA alterations in genes regulating cell metabolism. To determine the role of intratumoral metabolic differences, we examined single-cell RNA-sequencing (scRNA-seq) data from 34 additional patients. Findings on metabolic heterogeneity were correlated to clinical data.Established MB groups exhibit substantial differences in metabolic gene expression. By employing unsupervised analyses, we identified three clusters of group 3 and 4 samples with distinct metabolic features in ICGC and MAGIC cohorts. Analysis of scRNA-seq data confirmed our results of intertumoral heterogeneity underlying the according differences in metabolic gene expression. On DNA level, we discovered clear associations between altered regulatory genes involved in MB development and lipid metabolism. Additionally, we determined the prognostic value of metabolic gene expression in MB and showed that expression of genes involved in metabolism of inositol phosphates and nucleotides correlates with patient survival.Our research underlines the biological and clinical relevance of metabolic alterations in MB. Thus, distinct metabolic signatures presented here might be the first step towards future metabolism-targeted therapeutic options.
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000276420 650_7 $$2Other$$aInositol phosphates
000276420 650_7 $$2Other$$aMedulloblastoma
000276420 650_7 $$2Other$$aMetabolism
000276420 650_7 $$2Other$$aNucleotides
000276420 650_7 $$2Other$$aRNA-Seq
000276420 7001_ $$aWalter, Carolin$$b1
000276420 7001_ $$aMelcher, Viktoria$$b2
000276420 7001_ $$aWei, Lanying$$b3
000276420 7001_ $$aSandmann, Sarah$$b4
000276420 7001_ $$aHotfilder, Marc$$b5
000276420 7001_ $$aVarghese, Julian$$b6
000276420 7001_ $$0P:(DE-He78)bff9e3e3d86865d2b0836bb8f3ce98f3$$aJäger, Natalie$$b7$$udkfz
000276420 7001_ $$0P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aKool, Marcel$$b8$$udkfz
000276420 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David T W$$b9$$udkfz
000276420 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan M$$b10$$udkfz
000276420 7001_ $$0P:(DE-He78)0be2f86573954f87e97f8a4dbb05cb0f$$aMilde, Till$$b11$$udkfz
000276420 7001_ $$aMynarek, Martin$$b12
000276420 7001_ $$aRutkowski, Stefan$$b13
000276420 7001_ $$aSeggewiss, Jochen$$b14
000276420 7001_ $$aJeising, Daniela$$b15
000276420 7001_ $$ade Faria, Flavia W$$b16
000276420 7001_ $$aMarquardt, Thorsten$$b17
000276420 7001_ $$aAlbert, Thomas K$$b18
000276420 7001_ $$aSchüller, Ulrich$$b19
000276420 7001_ $$00000-0002-5676-8102$$aKerl, Kornelius$$b20
000276420 773__ $$0PERI:(DE-600)2118570-0$$a10.1186/s12967-023-04211-6$$gVol. 21, no. 1, p. 363$$n1$$p363$$tJournal of translational medicine$$v21$$x1479-5876$$y2023
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