TY  - JOUR
AU  - Kalkavan, Halime
AU  - Rühl, Sebastian
AU  - Shaw, Jeremy J P
AU  - Green, Douglas R
TI  - Non-lethal outcomes of engaging regulated cell death pathways in cancer.
JO  - Nature cancer
VL  - 4
IS  - 6
SN  - 2662-1347
CY  - London
PB  - Nature Research
M1  - DKFZ-2023-01109
SP  - 795-806
PY  - 2023
N1  - 2023 Jun;4(6):795-806
AB  - Regulated cell death (RCD) is essential for successful systemic cancer therapy. Yet, the engagement of RCD pathways does not inevitably result in cell death. Instead, RCD pathways can take part in diverse biological processes if the cells survive. Consequently, these surviving cells, for which we propose the term 'flatliners', harbor important functions. These evolutionarily conserved responses can be exploited by cancer cells to promote their own survival and growth, with challenges and opportunities for cancer therapy.
LB  - PUB:(DE-HGF)16
C6  - pmid:37277528
DO  - DOI:10.1038/s43018-023-00571-6
UR  - https://inrepo02.dkfz.de/record/276426
ER  -