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@ARTICLE{Bertschi:276717,
      author       = {S. Bertschi and K. Stützer and J. Berthold and J. Pietsch
                      and J. Smeets and G. Janssens and C. Richter$^*$},
      title        = {{P}otential margin reduction in prostate cancer proton
                      therapy with prompt gamma imaging for online treatment
                      verification},
      journal      = {Physics $\&$ Imaging in Radiation Oncology},
      volume       = {26},
      issn         = {2405-6316},
      address      = {Amsterdam [u. a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2023-01110},
      pages        = {100447},
      year         = {2023},
      abstract     = {The potential of proton therapy is currently limited due to
                      large safety margins. We estimated the potentialreduction of
                      clinical margins when using prompt gamma imaging (PGI) for
                      online treatment verification ofprostate cancer. For two
                      adaptive scenarios a potential reduction relative to
                      clinical practice was evaluated. Theuse of a trolley-mounted
                      PGI system for online treatment verification to trigger an
                      adaptation reduced the currentrange margins from 7 mm to 3
                      mm. In a case example, the dose reduction due to reduced
                      range margins wassubstantially larger compared to reduced
                      setup margins when using pre-treatment volumetric imaging.},
      cin          = {DD01},
      ddc          = {610},
      cid          = {I:(DE-He78)DD01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.phro.2023.100447},
      url          = {https://inrepo02.dkfz.de/record/276717},
}