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@ARTICLE{TauzideEspariat:276752,
      author       = {A. Tauziède-Espariat and S. Pfister$^*$ and C. Mawrin and
                      F. Sahm$^*$},
      title        = {{P}ediatric meningiomas: {A} literature review and
                      diagnostic update.},
      journal      = {Neuro-oncology advances},
      volume       = {5},
      number       = {Suppl 1},
      issn         = {2632-2498},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2023-01133},
      pages        = {105-111},
      year         = {2023},
      note         = {#LA:B300#},
      abstract     = {Meningiomas have always represented the most frequently
                      observed primary central nervous system (CNS) tumor in
                      adults. Multiple advances concerning the genetic and
                      epigenetic characterizations of adult meningiomas have been
                      made over the last few years, and a new proposition for
                      integrated histo-molecular grading has recently been offered
                      in the literature. Pediatric meningiomas represent a very
                      small proportion of all diagnosed meningiomas. New
                      literature has determined that pediatric meningiomas are
                      clinically, histopathologically, genetically, and
                      epigenetically distinct from their adult counterparts.
                      Herein, we reviewed and performed a synthesis of literature
                      investigating pediatric meningiomas. We then compared and
                      contrasted pediatric meningiomas with their adult
                      counterparts.We performed an extensive review of cases from
                      English-language literature available in Pubmed using the
                      keywords 'pediatric' and 'meningioma' as well as 'children'
                      and 'meningioma'. We reviewed and analyzed fifty-six papers
                      that include 498 cases.This literature review revealed that
                      pediatric meningiomas differ from their adult counterparts
                      clinically (location, sex ratio) and also in terms of
                      etiology (germline mutations), histopathology (a greater
                      incidence of clear cell subtype), molecular biology, and
                      epigenetics.Pediatric meningiomas are, like other brain
                      tumors (such as low-grade and high-grade gliomas),
                      clinically and biologically different from their adult
                      counterparts. Further studies are needed to better
                      understand the tumorigenesis of pediatric meningiomas and to
                      optimize their stratification in terms of outcome and
                      therapeutic strategy.},
      keywords     = {meningioma (Other) / pediatric (Other)},
      cin          = {B062 / HD01 / B300},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)B300-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37287580},
      pmc          = {pmc:PMC10243870},
      doi          = {10.1093/noajnl/vdac165},
      url          = {https://inrepo02.dkfz.de/record/276752},
}