%0 Journal Article
%A Watanabe, Masao
%A Grafe, Hong
%A Theysohn, Jens
%A Schaarschmidt, Benedikt
%A Ludwig, Johannes
%A Jochheim, Leonie
%A Jeschke, Matthias
%A Schmidt, Hartmut
%A Fendler, Wolfgang P
%A Moraitis, Alexandros
%A Herrmann, Ken
%A Pomykala, Kelsey L
%A Weber, Manuel
%T Voxel-Based Dosimetry Predicts Hepatotoxicity in Hepatocellular Carcinoma Patients Undergoing Radioembolization with 90Y Glass Microspheres.
%J Journal of nuclear medicine
%V 64
%N 7
%@ 0097-9058
%C New York, NY
%I Soc.
%M DKFZ-2023-01139
%P 1102-1108
%D 2023
%Z 2023 Jul;64(7):1102-1108
%X Personalized dosimetry holds promise to improve radioembolization treatment outcomes in hepatocellular carcinoma (HCC) patients. To this end, tolerance absorbed doses for nontumor liver tissue are assessed by calculating the mean absorbed dose to the whole nontumor liver tissue (AD-WNTLT), which may be limited by its neglect of nonuniform dose distribution. Thus, we analyzed whether voxel-based dosimetry could be more accurate in predicting hepatotoxicity in HCC patients undergoing radioembolization. Methods: In total, 176 HCC patients were available for this retrospective analysis; of these, 78 underwent partial- and 98 whole-liver treatment. Posttherapeutic changes in bilirubin were graded using the Common Terminology Criteria for Adverse Events. We performed voxel-based and multicompartment dosimetry using pretherapeutic 99mTc-labeled human serum albumin SPECT and contrast-enhanced CT/MRI and defined the following dosimetry parameters: AD-WNTLT; the nontumor liver tissue volume exposed to at least 20 Gy (V20), at least 30 Gy (V30), and at least 40 Gy (V40); and the threshold absorbed dose to the 20
%K SIRT (Other)
%K liver toxicity (Other)
%K multicompartment dosimetry (Other)
%K radioembolization (Other)
%K voxel-based dosimetry (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37290792
%R 10.2967/jnumed.122.264996
%U https://inrepo02.dkfz.de/record/276758