%0 Journal Article
%A Ng, Chia Huan
%A Obrecht, Denise
%A Wells, Olivia
%A Zapotocky, Michal
%A Sumerauer, David
%A Coltin, Hallie
%A Khuong-Quang, Dong-Anh
%A Eisenstat, David D
%A Kinross, Kathryn M
%A White, Christine L
%A Algar, Elizabeth M
%A Luck, Amanda
%A Witt, Hendrik
%A Schüller, Ulrich
%A Mynarek, Martin
%A Pietsch, Torsten
%A Gerber, Nicolas U
%A Benesch, Martin
%A Warmuth-Metz, Monika
%A Kortmann, Rolf
%A Bison, Brigitte
%A Taylor, Michael D
%A Rutkowski, Stefan
%A Pfister, Stefan M
%A Jones, David Tw
%A Gottardo, Nicholas G
%A von Hoff, Katja
%A Pajtler, Kristian
%A Ramaswamy, Vijay
%A Hansford, Jordan R
%T A multi-institutional retrospective pooled outcome analysis of molecularly annotated pediatric supratentorial ZFTA-fused ependymoma.
%J Neuro-oncology advances
%V 5
%N 1
%@ 2632-2498
%C Oxford
%I Oxford University Press
%M DKFZ-2023-01142
%P vdad057
%D 2023
%X ZFTA-RELA (formerly known as c11orf-RELA) fused supratentorial ependymoma (ZFTAfus ST-EPN) has been recognized as a novel entity in the 2016 WHO classification of CNS tumors and further defined in the recent 2021 edition. ZFTAfus ST-EPN was reported to portend poorer prognosis when compared to its counterpart, YAP1 ST-EPN in some previously published series. The aim of this study was to determine the treatment outcome of molecularly confirmed and conventionally treated ZFTAfus ST-EPN patients treated in multiple institutions.We conducted a retrospective analysis of all pediatric patients with molecularly confirmed ZFTAfus ST-EPN patients treated in multiple institutions in 5 different countries (Australia, Canada, Germany, Switzerland, and Czechia). Survival outcomes were analyzed and correlated with clinical characteristics and treatment approaches.A total of 108 patients were collated from multiple institutions in 5 different countries across three continents. We found across the entire cohort that the 5- and 10-year PFS were 65
%K ZFTA-RELA (Other)
%K central nervous system tumors (Other)
%K molecular  (Other)
%K pediatric (Other)
%K supratentorial ependymoma (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37287693
%2 pmc:PMC10243832
%R 10.1093/noajnl/vdad057
%U https://inrepo02.dkfz.de/record/276761