% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Striese:276772,
      author       = {F. Striese and C. Neuber and S. Gräßel and C. Arndt and
                      M. Ullrich and J. Steinbach and J. Pietzsch and R. Bergmann
                      and H.-J. Pietzsch and W. Sihver and M. Frenz and A.
                      Feldmann and M. P. Bachmann$^*$},
      title        = {{P}reclinical {C}haracterization of the 177{L}u-{L}abeled
                      {P}rostate {S}tem {C}ell {A}ntigen ({PSCA})-{S}pecific
                      {M}onoclonal {A}ntibody 7{F}5.},
      journal      = {International journal of molecular sciences},
      volume       = {24},
      number       = {11},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {DKFZ-2023-01153},
      pages        = {9420},
      year         = {2023},
      abstract     = {Prostate specific membrane antigen (PSMA) is an excellent
                      target for imaging and treatment of prostate carcinoma
                      (PCa). Unfortunately, not all PCa cells express PSMA.
                      Therefore, alternative theranostic targets are required. The
                      membrane protein prostate stem cell antigen (PSCA) is highly
                      overexpressed in most primary prostate carcinoma (PCa) cells
                      and in metastatic and hormone refractory tumor cells.
                      Moreover, PSCA expression positively correlates with tumor
                      progression. Therefore, it represents a potential
                      alternative theranostic target suitable for imaging and/or
                      radioimmunotherapy. In order to support this working
                      hypothesis, we conjugated our previously described anti-PSCA
                      monoclonal antibody (mAb) 7F5 with the bifunctional chelator
                      CHX-A″-DTPA and subsequently radiolabeled it with the
                      theranostic radionuclide 177Lu. The resulting radiolabeled
                      mAb ([177Lu]Lu-CHX-A″-DTPA-7F5) was characterized both in
                      vitro and in vivo. It showed a high radiochemical purity
                      $(>95\%)$ and stability. The labelling did not affect its
                      binding capability. Biodistribution studies showed a high
                      specific tumor uptake compared to most non-targeted tissues
                      in mice bearing PSCA-positive tumors. Accordingly, SPECT/CT
                      images revealed a high tumor-to-background ratios from 16 h
                      to 7 days after administration of
                      [177Lu]Lu-CHX-A″-DTPA-7F5. Consequently,
                      [177Lu]Lu-CHX-A″-DTPA-7F5 represents a promising candidate
                      for imaging and in the future also for radioimmunotherapy.},
      keywords     = {Animals / Mice / Male / Pentetic Acid: chemistry / Tissue
                      Distribution / Prostate / Cell Line, Tumor / Antibodies,
                      Monoclonal: therapeutic use / Antibodies, Monoclonal:
                      chemistry / Stem Cells / Carcinoma: drug therapy / Lutetium:
                      chemistry / 177Lu-labeled antibody (Other) / CHX-A″-DTPA
                      (Other) / prostate cancer (Other) / prostate stem cell
                      antigen (Other) / Pentetic Acid (NLM Chemicals) /
                      Antibodies, Monoclonal (NLM Chemicals) / Lutetium (NLM
                      Chemicals)},
      cin          = {DD01},
      ddc          = {540},
      cid          = {I:(DE-He78)DD01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37298374},
      pmc          = {pmc:PMC10253363},
      doi          = {10.3390/ijms24119420},
      url          = {https://inrepo02.dkfz.de/record/276772},
}