000276784 001__ 276784
000276784 005__ 20240229155004.0
000276784 0247_ $$2doi$$a10.2478/acph-2023-0019
000276784 0247_ $$2pmid$$apmid:37307368
000276784 0247_ $$2ISSN$$a1330-0075
000276784 0247_ $$2ISSN$$a1846-9558
000276784 037__ $$aDKFZ-2023-01159
000276784 041__ $$aEnglish
000276784 082__ $$a610
000276784 1001_ $$00000-0001-9971-9733$$aBaranasic, Jurica$$b0
000276784 245__ $$aGermline variants of the genes involved in NF-kB activation are associated with the risk of COPD and lung cancer development.
000276784 260__ $$aWarsaw$$bSciendo$$c2023
000276784 3367_ $$2DRIVER$$aarticle
000276784 3367_ $$2DataCite$$aOutput Types/Journal article
000276784 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1686653635_12252
000276784 3367_ $$2BibTeX$$aARTICLE
000276784 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000276784 3367_ $$00$$2EndNote$$aJournal Article
000276784 500__ $$a#EA:B062#
000276784 520__ $$aChronic obstructive pulmonary disease (COPD) and lung cancer (LC) are closely related diseases associated with smoking history and dysregulated immune response. However, not all smokers develop the disease, indicating that genetic susceptibility could be important. Therefore, the aim of this study was to search for the potential overlapping genetic biomarkers, with a focus on single nucleotide polymorphisms (SNPs) located in the regulatory regions of immune-related genes. Additionally, the aim was to see if an identified SNP has potentially an effect on proinflamma-tory cytokine concentration in the serum of COPD patients. We extracted summary data of variants in 1511 immune-related genes from COPD and LC genome-wide association studies (GWAS) from the UK Biobank. The LC data had 203 cases, patients diagnosed with LC, and 360 938 controls, while COPD data had 1 897 cases and 359 297 controls. Assuming 1 association/gene, SNPs with a p-value < 3.3 × 10-5 were considered statistically significantly associated with the disease. We identified seven SNPs located in different genes (BAG6, BTNL2, TNF, HCP5, MICB, NCR3, ABCF1, TCF7L1) to be associated with the COPD risk and two with the LC risk (HLA-C, HLA-B), with statistical significance. We also identified two SNPs located in the IL2RA gene associated with LC (rs2386841; p = 1.86 × 10-4) and COPD (rs11256442; p = 9.79 × 10-3) but with lower significance. Functional studies conducted on COPD patients showed that RNA expression of IL2RA, IFNγ and related proinflammatory cytokines in blood serum did not correlate with a specific genotype. Although results presented in this study do not fully support our hypothesis, it is worth to mention that the identified genes/SNPs that were associated with either COPD or LC risk, all were involved in the activation of the NF-κB transcription factor which is closely related to the regulation of the inflammatory response, a condition associated with both pathologies.
000276784 536__ $$0G:(DE-HGF)POF4-312$$a312 - Funktionelle und strukturelle Genomforschung (POF4-312)$$cPOF4-312$$fPOF IV$$x0
000276784 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000276784 650_7 $$2Other$$aCOPD
000276784 650_7 $$2Other$$aGWAS
000276784 650_7 $$2Other$$aNF-κB
000276784 650_7 $$2Other$$aSNP
000276784 650_7 $$2Other$$aimmune-related genes
000276784 650_7 $$2Other$$alung cancer
000276784 7001_ $$0P:(DE-He78)0681b959321f574e7ad1869cc3011346$$aNiazi, Yasmeen$$b1$$eFirst author$$udkfz
000276784 7001_ $$0P:(DE-He78)9918be87133a5ff93034e03087506c3c$$aChattopadhyay, Subhayan$$b2
000276784 7001_ $$00000-0002-5302-3770$$aRumora, Lada$$b3
000276784 7001_ $$aĆorak, Lorna$$b4
000276784 7001_ $$00000-0002-1522-3325$$aDugac, Andrea Vukić$$b5
000276784 7001_ $$00000-0002-4815-7512$$aJakopović, Marko$$b6
000276784 7001_ $$aSamaržija, Miroslav$$b7
000276784 7001_ $$0P:(DE-He78)f26164c08f2f14abcf31e52e13ee3696$$aFörsti, Asta$$b8$$udkfz
000276784 7001_ $$aKnežević, Jelena$$b9
000276784 773__ $$0PERI:(DE-600)2255569-9$$a10.2478/acph-2023-0019$$gVol. 73, no. 2, p. 243 - 256$$n2$$p243 - 256$$tActa pharmaceutica$$v73$$x1330-0075$$y2023
000276784 909CO $$ooai:inrepo02.dkfz.de:276784$$pVDB
000276784 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)0681b959321f574e7ad1869cc3011346$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000276784 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)9918be87133a5ff93034e03087506c3c$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000276784 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)f26164c08f2f14abcf31e52e13ee3696$$aDeutsches Krebsforschungszentrum$$b8$$kDKFZ
000276784 9131_ $$0G:(DE-HGF)POF4-312$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vFunktionelle und strukturelle Genomforschung$$x0
000276784 9141_ $$y2023
000276784 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2022-02-28T14:12:39Z
000276784 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2022-02-28T14:12:39Z
000276784 915__ $$0LIC:(DE-HGF)CCBYNCNDNV$$2V:(DE-HGF)$$aCreative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND (No Version)$$bDOAJ$$d2022-02-28T14:12:39Z
000276784 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2022-11-17
000276784 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2022-11-17
000276784 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2022-11-17
000276784 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2022-11-17
000276784 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2022-11-17
000276784 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-25
000276784 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-25
000276784 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-25
000276784 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-10-25
000276784 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-25
000276784 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Double anonymous peer review$$d2022-02-28T14:12:39Z
000276784 9201_ $$0I:(DE-He78)B062-20160331$$kB062$$lB062 Pädiatrische Neuroonkologie$$x0
000276784 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x1
000276784 9200_ $$0I:(DE-He78)B062-20160331$$kB062$$lB062 Pädiatrische Neuroonkologie$$x0
000276784 980__ $$ajournal
000276784 980__ $$aVDB
000276784 980__ $$aI:(DE-He78)B062-20160331
000276784 980__ $$aI:(DE-He78)HD01-20160331
000276784 980__ $$aUNRESTRICTED