%0 Journal Article
%A Chung, Felicia Fei-Lei
%A Maldonado, Sandra González
%A Nemc, Amelie
%A Bouaoun, Liacine
%A Cahais, Vincent
%A Cuenin, Cyrille
%A Salle, Aurelie
%A Johnson, Theron
%A Ergüner, Bekir
%A Laplana, Marina
%A Datlinger, Paul
%A Jeschke, Jana
%A Weiderpass, Elisabete
%A Kristensen, Vessela
%A Delaloge, Suzette
%A Fuks, François
%A Risch, Angela
%A Ghantous, Akram
%A Plass, Christoph
%A Bock, Christoph
%A Kaaks, Rudolf
%A Herceg, Zdenko
%T Buffy coat signatures of breast cancer risk in a prospective cohort study.
%J Clinical epigenetics
%V 15
%N 1
%@ 1868-7075
%C [Erscheinungsort nicht ermittelbar]
%I BioMed Central
%M DKFZ-2023-01162
%P 102
%D 2023
%Z #EA:C020#LA:C020#
%X Epigenetic alterations are a near-universal feature of human malignancy and have been detected in malignant cells as well as in easily accessible specimens such as blood and urine. These findings offer promising applications in cancer detection, subtyping, and treatment monitoring. However, much of the current evidence is based on findings in retrospective studies and may reflect epigenetic patterns that have already been influenced by the onset of the disease.Studying breast cancer, we established genome-scale DNA methylation profiles of prospectively collected buffy coat samples (n = 702) from a case-control study nested within the EPIC-Heidelberg cohort using reduced representation bisulphite sequencing (RRBS).We observed cancer-specific DNA methylation events in buffy coat samples. Increased DNA methylation in genomic regions associated with SURF6 and REXO1/CTB31O20.3 was linked to the length of time to diagnosis in the prospectively collected buffy coat DNA from individuals who subsequently developed breast cancer. Using machine learning methods, we piloted a DNA methylation-based classifier that predicted case-control status in a held-out validation set with 76.5
%K Breast cancer (Other)
%K Cancer risk markers (Other)
%K DNA methylation (Other)
%K Epigenetics (Other)
%K Prospective cohort (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37309009
%R 10.1186/s13148-023-01509-6
%U https://inrepo02.dkfz.de/record/276787