TY  - JOUR
AU  - Chung, Felicia Fei-Lei
AU  - Maldonado, Sandra González
AU  - Nemc, Amelie
AU  - Bouaoun, Liacine
AU  - Cahais, Vincent
AU  - Cuenin, Cyrille
AU  - Salle, Aurelie
AU  - Johnson, Theron
AU  - Ergüner, Bekir
AU  - Laplana, Marina
AU  - Datlinger, Paul
AU  - Jeschke, Jana
AU  - Weiderpass, Elisabete
AU  - Kristensen, Vessela
AU  - Delaloge, Suzette
AU  - Fuks, François
AU  - Risch, Angela
AU  - Ghantous, Akram
AU  - Plass, Christoph
AU  - Bock, Christoph
AU  - Kaaks, Rudolf
AU  - Herceg, Zdenko
TI  - Buffy coat signatures of breast cancer risk in a prospective cohort study.
JO  - Clinical epigenetics
VL  - 15
IS  - 1
SN  - 1868-7075
CY  - [Erscheinungsort nicht ermittelbar]
PB  - BioMed Central
M1  - DKFZ-2023-01162
SP  - 102
PY  - 2023
N1  - #EA:C020#LA:C020#
AB  - Epigenetic alterations are a near-universal feature of human malignancy and have been detected in malignant cells as well as in easily accessible specimens such as blood and urine. These findings offer promising applications in cancer detection, subtyping, and treatment monitoring. However, much of the current evidence is based on findings in retrospective studies and may reflect epigenetic patterns that have already been influenced by the onset of the disease.Studying breast cancer, we established genome-scale DNA methylation profiles of prospectively collected buffy coat samples (n = 702) from a case-control study nested within the EPIC-Heidelberg cohort using reduced representation bisulphite sequencing (RRBS).We observed cancer-specific DNA methylation events in buffy coat samples. Increased DNA methylation in genomic regions associated with SURF6 and REXO1/CTB31O20.3 was linked to the length of time to diagnosis in the prospectively collected buffy coat DNA from individuals who subsequently developed breast cancer. Using machine learning methods, we piloted a DNA methylation-based classifier that predicted case-control status in a held-out validation set with 76.5
KW  - Breast cancer (Other)
KW  - Cancer risk markers (Other)
KW  - DNA methylation (Other)
KW  - Epigenetics (Other)
KW  - Prospective cohort (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37309009
DO  - DOI:10.1186/s13148-023-01509-6
UR  - https://inrepo02.dkfz.de/record/276787
ER  -