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000276866 1001_ $$0P:(DE-He78)a803bc5fee5b7b2093f0fe6074f3d2ea$$aKroh, Florian$$b0$$eFirst author$$udkfz
000276866 245__ $$aSemi-solid MT and APTw CEST-MRI predict clinical outcome of patients with glioma early after radiotherapy.
000276866 260__ $$aNew York, NY [u.a.]$$bWiley-Liss$$c2023
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000276866 500__ $$a#EA:E010#EA:E020#LA:E010# / 2023 Oct;90(4):1569-1581
000276866 520__ $$aThe purpose of this study was to compare the potential of asymmetry-based (APTwasym ), Lorentzian-fit-based (PeakAreaAPT and MTconst ), and relaxation-compensated (MTRRex APT and MTRRex MT) CEST contrasts of the amide proton transfer (APT) and semi-solid magnetization transfer (ssMT) for early response assessment and prediction of progression-free survival (PFS) in patients with glioma.Seventy-two study participants underwent CEST-MRI at 3T from July 2018 to December 2021 in a prospective clinical trial four to 6 wk after the completion of radiotherapy for diffuse glioma. Tumor segmentations were performed on T2w -FLAIR and contrast-enhanced T1w images. Therapy response assessment and determination of PFS were performed according to response assessment in neuro oncology (RANO) criteria using clinical follow-up data with a median observation time of 9.2 mo (range, 1.6-40.8) and compared to CEST MRI metrics. Statistical testing included receiver operating characteristic analyses, Mann-Whitney-U-test, Kaplan-Meier analyses, and logrank-test.MTconst (AUC = 0.79, p < 0.01) showed a stronger association with RANO response assessment compared to PeakAreaAPT (AUC = 0.71, p = 0.02) and MTRRex MT (AUC = 0.71, p = 0.02), and enabled differentiation of participants with pseudoprogression (n = 8) from those with true progression (AUC = 0.79, p = 0.02). Furthermore, MTconst (HR = 3.04, p = 0.01), PeakAreaAPT (HR = 0.39, p = 0.03), and APTwasym (HR = 2.63, p = 0.02) were associated with PFS. MTRRex APT was not associated with any outcome.MTconst , PeakAreaAPT, and APTwasym imaging predict clinical outcome by means of progression-free survival. Furthermore, MTconst enables differentiation of radiation-induced pseudoprogression from disease progression. Therefore, the assessed metrics may have synergistic potential for supporting clinical decision making during follow-up of patients with glioma.
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000276866 650_7 $$2Other$$aamide proton transfer imaging
000276866 650_7 $$2Other$$achemical exchange saturation transfer
000276866 650_7 $$2Other$$aglioma
000276866 650_7 $$2Other$$amagnetic resonance imaging
000276866 650_7 $$2Other$$aradiotherapy
000276866 650_7 $$2Other$$asemisolid magnetization transfer imaging
000276866 7001_ $$0P:(DE-He78)857bbcdb8f5f582e00795df8b957767d$$avon Knebel Doeberitz, Nikolaus$$b1$$eFirst author$$udkfz
000276866 7001_ $$0P:(DE-He78)8a54e49721e8ba58de289702bad026d9$$aBreitling, Johannes$$b2
000276866 7001_ $$0P:(DE-He78)2125f6b64a5de735c85e8f646edef7a9$$aMaksimovic, Srdjan$$b3
000276866 7001_ $$aKönig, Laila$$b4
000276866 7001_ $$aAdeberg, Sebastian$$b5
000276866 7001_ $$aScherer, Moritz$$b6
000276866 7001_ $$aUnterberg, Andreas$$b7
000276866 7001_ $$aBendszus, Martin$$b8
000276866 7001_ $$aWick, Wolfgang$$b9
000276866 7001_ $$0P:(DE-He78)29b2f01310f7022916255ddba2750f9b$$aBachert, Peter$$b10$$udkfz
000276866 7001_ $$0P:(DE-He78)8714da4e45acfa36ce87c291443a9218$$aDebus, Jürgen$$b11$$udkfz
000276866 7001_ $$0P:(DE-He78)022611a2317e4de40fd912e0a72293a8$$aLadd, Mark E$$b12$$udkfz
000276866 7001_ $$0P:(DE-He78)3d04c8fee58c9ab71f62ff80d06b6fec$$aSchlemmer, Heinz-Peter$$b13$$udkfz
000276866 7001_ $$0P:(DE-He78)577a5c61f44b8023e229610afbc7cd4e$$aKorzowski, Andreas$$b14$$udkfz
000276866 7001_ $$0P:(DE-HGF)0$$aGoerke, Steffen$$b15
000276866 7001_ $$0P:(DE-He78)c6e31fb8f19e185e254174554a0cccfc$$aPaech, Daniel$$b16$$eLast author$$udkfz
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