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@ARTICLE{Zaun:276877,
      author       = {G. Zaun and M. Weber and M. Metzenmacher and M. Wiesweg and
                      T. Hilser and Y. Zaun and S. Liffers$^*$ and M. Pogorzelski
                      and I. Virchow and W. Eberhardt and S. Theurer and T. A.
                      Sabbah and T. M. Reissig and M. Stuschke and C. Kürten and
                      T. Hussain and S. Lang and S. Kasper$^*$ and W. Fendler and
                      K. Herrmann and M. Schuler$^*$},
      title        = {{SUV}max {A}bove 20 in 18{F}-{FDG} {PET}/{CT} at {I}nitial
                      {D}iagnostic {W}orkup {A}ssociates with {F}avorable
                      {S}urvival in {P}atients with {C}ancer of {U}nknown
                      {P}rimary.},
      journal      = {Journal of nuclear medicine},
      volume       = {64},
      number       = {8},
      issn         = {0097-9058},
      address      = {New York, NY},
      publisher    = {Soc.},
      reportid     = {DKFZ-2023-01186},
      pages        = {1191-1194},
      year         = {2023},
      note         = {2023 Aug;64(8):1191-1194},
      abstract     = {Cancer of unknown primary (CUP) is a heterogeneous entity
                      with a limited prognosis. Novel prognostic markers are
                      needed for patient stratification in prospective clinical
                      trials exploring innovative therapies. Methods: In CUP
                      patients treated at the West German Cancer Center Essen, the
                      prognostic value of 18F-FDG PET/CT at the initial diagnostic
                      workup was analyzed by comparing overall survival (OS) in
                      patients who underwent 18F-FDG PET/CT with those who did
                      not. Results: Of 154 patients with a CUP diagnosis, 76
                      underwent 18F-FDG PET/CT at the initial diagnostic workup.
                      The median overall survival (OS) of the full analysis set
                      was 20.0 mo. Within the PET/CT subgroup, an SUVmax above 20
                      was associated with significantly superior OS (median OS,
                      not reached vs. 32.0 mo; hazard ratio, 0.261; $95\%$ CI,
                      0.095-0.713; P = 0.009). Conclusion: Our retrospective work
                      shows that an SUVmax above 20 on 18F-FDG PET/CT at the
                      initial diagnostic workup is a favorable prognostic factor
                      in patients with CUP. This finding deserves further
                      prospective studies for validation.},
      keywords     = {18F-FDG PET/CT (Other) / CUP (Other) / SUVmax (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37321823},
      doi          = {10.2967/jnumed.122.265161},
      url          = {https://inrepo02.dkfz.de/record/276877},
}