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000276895 1001_ $$00000-0003-4231-5740$$aClasen, Joanna L$$b0
000276895 245__ $$aReproductive and hormonal factors and risk of renal cell carcinoma among women in the European Prospective Investigation into Cancer and Nutrition.
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000276895 520__ $$aRenal cell carcinoma (RCC) is twice as common among men compared with women, and hormonal factors have been suggested to partially explain this difference. There is currently little evidence on the roles of reproductive and hormonal risk factors in RCC aetiology.We investigated associations of age at menarche and age at menopause, pregnancy-related factors, hysterectomy and ovariectomy and exogenous hormone use with RCC risk among 298,042 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.During 15 years of follow-up, 438 RCC cases were identified. Parous women had higher rates of RCC compared with nulliparous women (HR = 1.71, 95% CI 1.18, 2.46), and women who were older at age of first pregnancy had lower rates of RCC (30 years + vs. <20 years HR = 0.53, 95% CI 0.34, 0.82). Additionally, we identified a positive association for hysterectomy (HR = 1.43 95% CI 1.09, 1.86) and bilateral ovariectomy (HR = 1.67, 95% CI 1.13, 2.47), but not unilateral ovariectomy (HR = 0.99, 95% CI 0.61, 1.62) with RCC risk. No clear associations were found for age at menarche, age at menopause or exogenous hormone use.Our results suggest that parity and reproductive organ surgeries may play a role in RCC aetiology.
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000276895 7001_ $$aMabunda, Rita$$b1
000276895 7001_ $$00000-0001-6517-1300$$aHeath, Alicia K$$b2
000276895 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b3$$udkfz
000276895 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b4$$udkfz
000276895 7001_ $$aSchulze, Matthias B$$b5
000276895 7001_ $$aBirukov, Anna$$b6
000276895 7001_ $$aTagliabue, Giovanna$$b7
000276895 7001_ $$aChiodini, Paolo$$b8
000276895 7001_ $$aTumino, Rosario$$b9
000276895 7001_ $$aMilani, Lorenzo$$b10
000276895 7001_ $$aBraaten, Tonje$$b11
000276895 7001_ $$aGram, Inger$$b12
000276895 7001_ $$00000-0002-3608-9743$$aLukic, Marko$$b13
000276895 7001_ $$aLuján-Barroso, Leila$$b14
000276895 7001_ $$aRodriguez-Barranco, Miguel$$b15
000276895 7001_ $$aChirlaque, María-Dolores$$b16
000276895 7001_ $$aArdanaz, Eva$$b17
000276895 7001_ $$aAmiano, Pilar$$b18
000276895 7001_ $$00000-0002-3158-5289$$aManjer, Jonas$$b19
000276895 7001_ $$00000-0002-8597-9224$$aHuss, Linnea$$b20
000276895 7001_ $$aLjungberg, Börje$$b21
000276895 7001_ $$aTravis, Ruth$$b22
000276895 7001_ $$aSmith-Byrne, Karl$$b23
000276895 7001_ $$aGunter, Marc$$b24
000276895 7001_ $$aJohansson, Matthias$$b25
000276895 7001_ $$00000-0002-6846-1204$$aRinaldi, Sabina$$b26
000276895 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b27
000276895 7001_ $$aRiboli, Elio$$b28
000276895 7001_ $$aCross, Amanda J$$b29
000276895 7001_ $$aMuller, David C$$b30
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