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@ARTICLE{Clasen:276895,
author = {J. L. Clasen and R. Mabunda and A. K. Heath and R.
Kaaks$^*$ and V. Katzke$^*$ and M. B. Schulze and A. Birukov
and G. Tagliabue and P. Chiodini and R. Tumino and L. Milani
and T. Braaten and I. Gram and M. Lukic and L.
Luján-Barroso and M. Rodriguez-Barranco and M.-D. Chirlaque
and E. Ardanaz and P. Amiano and J. Manjer and L. Huss and
B. Ljungberg and R. Travis and K. Smith-Byrne and M. Gunter
and M. Johansson and S. Rinaldi and E. Weiderpass and E.
Riboli and A. J. Cross and D. C. Muller},
title = {{R}eproductive and hormonal factors and risk of renal cell
carcinoma among women in the {E}uropean {P}rospective
{I}nvestigation into {C}ancer and {N}utrition.},
journal = {Cancer medicine},
volume = {12},
number = {14},
issn = {2045-7634},
address = {Hoboken, NJ},
publisher = {Wiley},
reportid = {DKFZ-2023-01197},
pages = {15588-15600},
year = {2023},
note = {2023 Jul;12(14):15588-15600},
abstract = {Renal cell carcinoma (RCC) is twice as common among men
compared with women, and hormonal factors have been
suggested to partially explain this difference. There is
currently little evidence on the roles of reproductive and
hormonal risk factors in RCC aetiology.We investigated
associations of age at menarche and age at menopause,
pregnancy-related factors, hysterectomy and ovariectomy and
exogenous hormone use with RCC risk among 298,042 women in
the European Prospective Investigation into Cancer and
Nutrition (EPIC) study.During 15 years of follow-up, 438 RCC
cases were identified. Parous women had higher rates of RCC
compared with nulliparous women (HR = 1.71, $95\%$ CI 1.18,
2.46), and women who were older at age of first pregnancy
had lower rates of RCC (30 years + vs. <20 years HR = 0.53,
$95\%$ CI 0.34, 0.82). Additionally, we identified a
positive association for hysterectomy (HR = 1.43 $95\%$ CI
1.09, 1.86) and bilateral ovariectomy (HR = 1.67, $95\%$ CI
1.13, 2.47), but not unilateral ovariectomy (HR = 0.99,
$95\%$ CI 0.61, 1.62) with RCC risk. No clear associations
were found for age at menarche, age at menopause or
exogenous hormone use.Our results suggest that parity and
reproductive organ surgeries may play a role in RCC
aetiology.},
cin = {C020},
ddc = {610},
cid = {I:(DE-He78)C020-20160331},
pnm = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
pid = {G:(DE-HGF)POF4-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:37269199},
doi = {10.1002/cam4.6207},
url = {https://inrepo02.dkfz.de/record/276895},
}