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@ARTICLE{Zhang:276912,
      author       = {K. S. Zhang$^*$ and C. J. O. Neelsen$^*$ and M.
                      Wennmann$^*$ and P. A. Glemser$^*$ and T. Hielscher$^*$ and
                      V. Weru$^*$ and M. Görtz$^*$ and V. Schütz and A.
                      Stenzinger and M. Hohenfellner and H.-P. Schlemmer$^*$ and
                      D. Bonekamp$^*$},
      title        = {{S}ame-day repeatability and {B}etween-{S}equence
                      reproducibility of {M}ean {ADC} in {PI}-{RADS} lesions.},
      journal      = {European journal of radiology},
      volume       = {165},
      issn         = {0720-048x},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2023-01205},
      pages        = {110898},
      year         = {2023},
      note         = {#EA:E010#LA:E010#},
      abstract     = {This study aimed to assess repeatability after
                      repositioning (inter-scan), intra-rater, inter-rater and
                      inter-sequence variability of mean apparent diffusion
                      coefficient (ADC) measurements in MRI-detected prostate
                      lesions.Forty-three patients with suspicion for prostate
                      cancer were included and received a clinical prostate
                      bi-/multiparametric MRI examination with repeat scans of the
                      T2-weighted and two DWI-weighted sequences (ssEPI and
                      rsEPI). Two raters (R1 and R2) performed single-slice, 2D
                      regions of interest (2D-ROIs) and 3D-segmentation-ROIs
                      (3D-ROIs). Mean bias, corresponding limits of agreement
                      (LoA), mean absolute difference, within-subject coefficient
                      of variation (CoV) and repeatability/reproducibility
                      coefficient (RC/RDC) were calculated. Bradley $\&$ Blackwood
                      test was used for variance comparison. Linear mixed models
                      (LMM) were used to account for multiple lesions per
                      patient.Inter-scan repeatability, intra-rater and
                      inter-sequence reproducibility analysis of ADC showed no
                      significant bias. 3D-ROIs demonstrated significantly less
                      variability than 2D-ROIs (p < 0.01). Inter-rater comparison
                      demonstrated small significant systematic bias of 57 × 10-6
                      mm2/s for 3D-ROIs (p < 0.001). Intra-rater RC, with the
                      lowest variation, was 145 and 189 × 10-6 mm2/s for 3D- and
                      2D-ROIs, respectively. For 3D-ROIs of ssEPI, RCs and RDCs
                      were 190-198 × 10-6 mm2/s for inter-scan, inter-rater and
                      inter-sequence variation. No significant differences were
                      found for inter-scan, inter-rater and inter-sequence
                      variability.In a single-scanner setting, single-slice ADC
                      measurements showed considerable variation, which may be
                      lowered using 3D-ROIs. For 3D-ROIs, we propose a cut-off of
                      ∼ 200 × 10-6 mm2/s for differences introduced by
                      repositioning, rater or sequence effects. The results
                      suggest that follow-up measurements should be possible by
                      different raters or sequences.},
      keywords     = {ADC (Other) / Apparent diffusion coefficient (Other) /
                      Prostate (Other) / Repeatability (Other) / Reproducibility
                      (Other) / Retest (Other) / Stability (Other) / Test (Other)},
      cin          = {E010 / C060 / E250 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)C060-20160331 /
                      I:(DE-He78)E250-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37331287},
      doi          = {10.1016/j.ejrad.2023.110898},
      url          = {https://inrepo02.dkfz.de/record/276912},
}