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@ARTICLE{Schmidt:276936,
      author       = {M. Schmidt$^*$ and M. Chong and O. Klassen and J. Wiskemann
                      and K. Steindorf$^*$},
      title        = {{L}ongitudinal associations of bioelectrical phase angle
                      and fatigue in breast cancer patients.},
      journal      = {International journal of cancer},
      volume       = {153},
      number       = {6},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2023-01213},
      pages        = {1192-1200},
      year         = {2023},
      note         = {#EA:C110#LA:C110# / 2023 Sep 15;153(6):1192-1200},
      abstract     = {Cancer-related fatigue is commonly treated in an
                      undifferentiated manner, because its pathophysiology is
                      still not well understood. Therefore, we investigated if
                      bioelectrical phase angle (PhA), a non-invasive marker of
                      cell integrity, could help to single out specific fatigue
                      subtypes. In a randomized controlled strength training
                      intervention trial, PhA was measured by bioelectrical
                      impedance analysis in 158 breast cancer patients. Fatigue
                      was assessed with the multidimensional 20-item Fatigue
                      Assessment Questionnaire. Multiple regression analyses
                      considering changes in PhA and fatigue from baseline to
                      post-intervention and ANCOVA models investigating the
                      strength training effect on PhA were conducted. Further,
                      explorative mediation and moderation analyses were
                      performed. Decrease (=worsening) in PhA was significantly
                      associated with increase in physical (P = .010) and
                      emotional (P = .019) fatigue. These associations were
                      markedly stronger in patients with normal BMI (interaction P
                      = .059 and .097) and with low pre-diagnosis exercise level
                      (interaction P = .058 and .19). Among patients with normal
                      BMI strength training was associated with an increase in PhA
                      (ANCOVA P = .059), but not among overweight/obese patients
                      (interaction P = .035). Chemotherapy was a major determinant
                      for low PhA, but PhA did not mediate the effect of
                      chemotherapy on fatigue. In conclusion, PhA has a
                      significant inverse association with physical and emotional
                      fatigue. This association is moderated by BMI and previous
                      exercise. Significant relationships of PhA were also
                      observed with chemotherapy and strength training. Thus, PhA
                      might be a marker that could help in the classification of
                      subtypes of fatigue with different pathophysiology, which
                      may require specifically tailored treatment. Further
                      research on this is warranted.},
      keywords     = {bioimpedance analysis (Other) / cancer-related fatigue
                      (Other) / exercise (Other) / quality of life (Other) /
                      survivorship (Other)},
      cin          = {C110},
      ddc          = {610},
      cid          = {I:(DE-He78)C110-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37337948},
      doi          = {10.1002/ijc.34630},
      url          = {https://inrepo02.dkfz.de/record/276936},
}