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@ARTICLE{Christakoudi:276938,
      author       = {S. Christakoudi and K. K. Tsilidis and L. Dossus and S.
                      Rinaldi and E. Weiderpass and C. S. Antoniussen and C. C.
                      Dahm and A. Tjønneland and L. Mellemkjær and V. Katzke$^*$
                      and R. Kaaks$^*$ and M. B. Schulze and G. Masala and S.
                      Grioni and S. Panico and R. Tumino and C. Sacerdote and A.
                      M. May and E. M. Monninkhof and J. R. Quirós and C. Bonet
                      and M.-J. Sánchez and P. Amiano and M.-D. Chirlaque and M.
                      Guevara and A. H. Rosendahl and T. Stocks and A.
                      Perez-Cornago and S. Tin Tin and A. K. Heath and E. K.
                      Aglago and L. Peruchet-Noray and H. Freisling and E. Riboli},
      title        = {{A} body shape index ({ABSI}) is associated inversely with
                      post-menopausal progesterone-receptor-negative breast cancer
                      risk in a large {E}uropean cohort.},
      journal      = {BMC cancer},
      volume       = {23},
      number       = {1},
      issn         = {1471-2407},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2023-01215},
      pages        = {562},
      year         = {2023},
      abstract     = {Associations of body shape with breast cancer risk,
                      independent of body size, are unclear because waist and hip
                      circumferences are correlated strongly positively with body
                      mass index (BMI).We evaluated body shape with the allometric
                      'a body shape index' (ABSI) and hip index (HI), which
                      compare waist and hip circumferences, correspondingly, among
                      individuals with the same weight and height. We examined
                      associations of ABSI, HI, and BMI (per one standard
                      deviation increment) with breast cancer overall, and
                      according to menopausal status at baseline, age at
                      diagnosis, and oestrogen and progesterone receptor status
                      (ER+/-PR+/-) in multivariable Cox proportional hazards
                      models using data from the European Prospective
                      Investigation into Cancer and Nutrition (EPIC) cohort.During
                      a mean follow-up of 14.0 years, 9011 incident breast cancers
                      were diagnosed among 218,276 women. Although there was
                      little evidence for association of ABSI with breast cancer
                      overall (hazard ratio HR = 0.984; $95\%$ confidence
                      interval: 0.961-1.007), we found borderline inverse
                      associations for post-menopausal women (HR = 0.971;
                      0.942-1.000; n = 5268 cases) and breast cancers diagnosed at
                      age ≥ 55 years (HR = 0.976; 0.951-1.002; n = 7043) and
                      clear inverse associations for ER + PR- subtypes (HR =
                      0.894; 0.822-0.971; n = 726) and ER-PR- subtypes (HR =
                      0.906; 0.835-0.983 n = 759). There were no material
                      associations with HI. BMI was associated strongly positively
                      with breast cancer overall (HR = 1.074; 1.049-1.098), for
                      post-menopausal women (HR = 1.117; 1.085-1.150), for cancers
                      diagnosed at age ≥ 55 years (HR = 1.104; 1.076-1.132), and
                      for ER + PR + subtypes (HR = 1.122; 1.080-1.165; n = 3101),
                      but not for PR- subtypes.In the EPIC cohort, abdominal
                      obesity evaluated with ABSI was not associated with breast
                      cancer risk overall but was associated inversely with the
                      risk of post-menopausal PR- breast cancer. Our findings
                      require validation in other cohorts and with a larger number
                      of PR- breast cancer cases.},
      keywords     = {Female / Humans / Middle Aged / Body Mass Index / Breast
                      Neoplasms: complications / Risk Factors / Progesterone /
                      Prospective Studies / Triple Negative Breast Neoplasms:
                      complications / Postmenopause / Somatotypes / ABSI (Other) /
                      Body shape (Other) / Breast cancer (Other) / Hip size
                      (Other) / Obesity (Other) / Waist size (Other) /
                      Progesterone (NLM Chemicals)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37337133},
      doi          = {10.1186/s12885-023-11056-1},
      url          = {https://inrepo02.dkfz.de/record/276938},
}