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001     276942
005     20240229155008.0
024 7 _ |a 10.1088/1361-6560/acdfb0
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024 7 _ |a 0031-9155
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024 7 _ |a 1361-6560
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037 _ _ |a DKFZ-2023-01219
041 _ _ |a English
082 _ _ |a 530
100 1 _ |a Christensen, Jeppe Brage
|0 0000-0002-6894-381X
|b 0
245 _ _ |a Optically stimulated luminescence detectors for dosimetry and LET measurements in light ion beams.
260 _ _ |a Bristol
|c 2023
|b IOP Publ.
336 7 _ |a article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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500 _ _ |a Phys. Med. Biol. 68 (2023) 155001
520 _ _ |a Objective: This work investigates the use of Al2O3:C and Al2O3:C,Mg optically stimulated luminescence (OSL) detectors to determine both the dose and the radiation quality in light ion beams. The radiation quality is here expressed through either the linear energy transfer (LET) or the closely related metric Qeff, which depends on the particle's speed and effective charge. The derived LET and Qeffvalues are applied to improve the dosimetry in light ion beams. Approach: OSL detectors were irradiated in mono-energetic1H-,4He-,12C-, and16O-ion beams. The OSL signal is associated with two emission bands that were separated using a pulsed stimulation technique and subjected to automatic corrections based on reference irradiations. Each emission band was investigated independently for dosimetry, and the ratio of the two emission intensities was parameterized as a function of fluence- and dose-averaged LET, as well as Qeff. The determined radiation quality was subsequently applied to correct the dose for ionization quenching. Main results: For both materials, the Qeffdeterminations in1H- and4He-ion beams are within 5 % of the Monte Carlo simulated values. Using the determined radiation quality metrics to correct the non-linear (ionization quenched) detector response leads to doses within 2 % of the reference doses. Significance: Al2O3:C and Al2O3:C,Mg OSL detectors are applicable for dosimetry and radiation quality estimations in1H- and4He-ions. Only Al2O3:C,Mg shows promising results for dosimetry in12C-ions. Across both materials and the investigated ions, the estimated Qeffvalues were less sensitive to the ion type than the estimated LET values. The reduced uncertainties suggest new possibilities for simultaneously estimating the physical and biological dose in particle therapy with OSL detectors. .
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650 _ 7 |a ionization quenching
|2 Other
650 _ 7 |a linear energy transfer (LET)
|2 Other
650 _ 7 |a optically stimulated luminescence (OSL)
|2 Other
650 _ 7 |a particle dosimetry
|2 Other
650 _ 7 |a particle therapy
|2 Other
700 1 _ |a Muñoz, Iván Domingo
|b 1
700 1 _ |a Bassler, Niels
|0 0000-0002-4160-1078
|b 2
700 1 _ |a Stengl, Christina
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700 1 _ |a Bossin, Lily
|b 4
700 1 _ |a Togno, Michele
|b 5
700 1 _ |a Safai, Sairos
|b 6
700 1 _ |a Jaekel, Oliver
|0 0000-0002-6056-9747
|b 7
700 1 _ |a Yukihara, Eduardo G
|b 8
773 _ _ |a 10.1088/1361-6560/acdfb0
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|t Physics in medicine and biology
|v 68
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910 1 _ |a Deutsches Krebsforschungszentrum
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